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Imaging of PARP1/2-Overexpressing Cancers with Novel AZD2281-Derived Probes
(2014-07-07)
Poly(ADP-ribose)polymerase-1 and -2 (PARP1/2) are nuclear proteins involved in DNA repair. Tumors with defects in homologous recombination, including BRCA1- and BRCA2-deficient cancers, have been shown to be sensitive to ...