Antibiotic exposure and resistance in mixed bacterial populations
View/ Open
Antibiotic Exposure.pdf (1.230Mb)
Access Status
Full text of the requested work is not available in DASH at this time ("restricted access"). For more information on restricted deposits, see our FAQ.Author
Published Version
https://doi.org/10.1016/0040-5809(87)90053-0Metadata
Show full item recordCitation
Garber, Alan M. 1987. Antibiotic exposure and resistance in mixed bacterial populations. Annals of Internal Medicine 32, no. 3:326-346.Abstract
Antibiotic use is often blamed for increases in the prevalence of infections due to antibiotic-resistant bacteria. This paper clarifies the effects of antibiotic exposure on bacterial antibiotic resistance by developing models that describe the growth of competing bacterial strains whose antibiotic sensitivities differ. The analysis generalizes logistic growth models to include first-order growth parameters that are arbitrary functions of antibiotic levels. It derives closed-form solutions for population size, composition, and average antibiotic sensitivities as functions of antibiotic exposure. Strategies to minimize the bacterial population size are analyzed in the context of the model. These heuristic models explore in formal terms the population dynamics thought to underlie resistance development.Citable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11595673
Collections
- HCA Scholarly Articles [622]
Contact administrator regarding this item (to report mistakes or request changes)