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dc.contributor.authorGarber, Alan M
dc.date.accessioned2014-01-28T19:50:50Z
dc.date.issued1987
dc.identifierQuick submit: 2013-12-17T11:20:59-05:00
dc.identifier.citationGarber, Alan M. 1987. Antibiotic exposure and resistance in mixed bacterial populations. Annals of Internal Medicine 32, no. 3:326-346.en_US
dc.identifier.issn0040-5809en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11595673
dc.description.abstractAntibiotic use is often blamed for increases in the prevalence of infections due to antibiotic-resistant bacteria. This paper clarifies the effects of antibiotic exposure on bacterial antibiotic resistance by developing models that describe the growth of competing bacterial strains whose antibiotic sensitivities differ. The analysis generalizes logistic growth models to include first-order growth parameters that are arbitrary functions of antibiotic levels. It derives closed-form solutions for population size, composition, and average antibiotic sensitivities as functions of antibiotic exposure. Strategies to minimize the bacterial population size are analyzed in the context of the model. These heuristic models explore in formal terms the population dynamics thought to underlie resistance development.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/0040-5809(87)90053-0en_US
dc.relation.isversionofhttp://www.sciencedirect.com/science/article/pii/0040580987900530en_US
dash.licenseMETA_ONLY
dc.titleAntibiotic exposure and resistance in mixed bacterial populationsen_US
dc.typeJournal Articleen_US
dc.date.updated2013-12-17T16:37:47Z
dc.description.versionVersion of Recorden_US
dc.rights.holderGarber AM
dc.relation.journalTheoretical Population Biologyen_US
dash.depositing.authorGarber, Alan M
dash.embargo.until10000-01-01
dc.identifier.doi10.1016/0040-5809(87)90053-0*
workflow.legacycommentsFLAG2: Must be dark in DASH. Need to obtain author's submitted version.en_US
dash.contributor.affiliatedGarber, Alan


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