Antibiotic exposure and resistance in mixed bacterial populations

Antibiotic exposure and resistance in mixed bacterial populations

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Antibiotic exposure and resistance in mixed bacterial populations

dc.contributor.author	Garber, Alan M
dc.date.accessioned	2014-01-28T19:50:50Z
dc.date.issued	1987
dc.identifier	Quick submit: 2013-12-17T11:20:59-05:00
dc.identifier.citation	Garber, Alan M. 1987. Antibiotic exposure and resistance in mixed bacterial populations. Annals of Internal Medicine 32, no. 3:326-346.	en_US
dc.identifier.issn	0040-5809	en_US
dc.identifier.uri	http://nrs.harvard.edu/urn-3:HUL.InstRepos:11595673
dc.description.abstract	Antibiotic use is often blamed for increases in the prevalence of infections due to antibiotic-resistant bacteria. This paper clarifies the effects of antibiotic exposure on bacterial antibiotic resistance by developing models that describe the growth of competing bacterial strains whose antibiotic sensitivities differ. The analysis generalizes logistic growth models to include first-order growth parameters that are arbitrary functions of antibiotic levels. It derives closed-form solutions for population size, composition, and average antibiotic sensitivities as functions of antibiotic exposure. Strategies to minimize the bacterial population size are analyzed in the context of the model. These heuristic models explore in formal terms the population dynamics thought to underlie resistance development.	en_US
dc.language.iso	en_US	en_US
dc.publisher	Elsevier	en_US
dc.relation.isversionof	10.1016/0040-5809(87)90053-0	en_US
dc.relation.isversionof	http://www.sciencedirect.com/science/article/pii/0040580987900530	en_US
dash.license	META_ONLY
dc.title	Antibiotic exposure and resistance in mixed bacterial populations	en_US
dc.type	Journal Article	en_US
dc.date.updated	2013-12-17T16:37:47Z
dc.description.version	Version of Record	en_US
dc.rights.holder	Garber AM
dc.relation.journal	Theoretical Population Biology	en_US
dash.depositing.author	Garber, Alan M
dash.embargo.until	10000-01-01