Antibiotic exposure and resistance in mixed bacterial populations

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Antibiotic exposure and resistance in mixed bacterial populations

Show simple item record Garber, Alan M 2014-01-28T19:50:50Z 1987
dc.identifier Quick submit: 2013-12-17T11:20:59-05:00
dc.identifier.citation Garber, Alan M. 1987. Antibiotic exposure and resistance in mixed bacterial populations. Annals of Internal Medicine 32, no. 3:326-346. en_US
dc.identifier.issn 0040-5809 en_US
dc.description.abstract Antibiotic use is often blamed for increases in the prevalence of infections due to antibiotic-resistant bacteria. This paper clarifies the effects of antibiotic exposure on bacterial antibiotic resistance by developing models that describe the growth of competing bacterial strains whose antibiotic sensitivities differ. The analysis generalizes logistic growth models to include first-order growth parameters that are arbitrary functions of antibiotic levels. It derives closed-form solutions for population size, composition, and average antibiotic sensitivities as functions of antibiotic exposure. Strategies to minimize the bacterial population size are analyzed in the context of the model. These heuristic models explore in formal terms the population dynamics thought to underlie resistance development. en_US
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.relation.isversionof 10.1016/0040-5809(87)90053-0 en_US
dc.relation.isversionof en_US
dash.license META_ONLY
dc.title Antibiotic exposure and resistance in mixed bacterial populations en_US
dc.type Journal Article en_US 2013-12-17T16:37:47Z
dc.description.version Version of Record en_US
dc.rights.holder Garber AM
dc.relation.journal Theoretical Population Biology en_US Garber, Alan M
dash.embargo.until 10000-01-01

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