Garber, Alan M. 1989. A discrete-time model of the acquisition of antibiotic-resistant infections in hospitalized patients. Biometrics 45, no. 3:797-816.
Antibiotic use is thought to promote bacterial antibiotic resistance by selectively inhibiting the growth of sensitive strains. This study investigates the relation between antibiotic use and the propagation of
antibiotic-resistant hospital-acquired infections due to gram-negative bacteria in a population of
hospitalized patients. It treats infection spread and hospital mortality as a Markov process, in which
the transition probabilities are logistic functions of a set of personal and hospital characteristics. Data
from a university hospital are used to derive the parameters of the model.