Comparative Lesion Sequencing Provides Insights into Tumor Evolution

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Comparative Lesion Sequencing Provides Insights into Tumor Evolution

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Title: Comparative Lesion Sequencing Provides Insights into Tumor Evolution
Author: Jones, Siân; Chen, Wei-dong; Parmigiani, Giovanni; Diehl, Frank; Beerenwinkel, Niko; Antal, Tibor; Traulsen, Arne; Nowak, Martin A.; Siegel, Christopher; Velculescu, Victor E.; Kinzler, Kenneth W.; Vogelstein, Bert; Willis, Joseph; Markowitz, Sanford D.

Note: Order does not necessarily reflect citation order of authors.

Citation: Jones, Siân, Wei-dong Chen, Giovanni Parmigiani, Frank Diehl, Niko Beerenwinkel, Tibor Antal, Arne Traulsen, et al. 2008. Comparative lesion sequencing provides insights into tumor evolution. Proceedings of the National Academy of Sciences 105(11): 4283-4288.
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Abstract: We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses suggest the following general conclusions about colorectal tumorigenesis: (i) It takes ≈17 years for a large benign tumor to evolve into an advanced cancer but <2 years for cells within that cancer to acquire the ability to metastasize; (ii) it requires few, if any, selective events to transform a highly invasive cancer cell into one with the capacity to metastasize; (iii) the process of cell culture ex vivo does not introduce new clonal mutations into colorectal tumor cell populations; and (iv) the rates at which point mutations develop in advanced cancers are similar to those of normal cells. These results have important implications for understanding human tumor pathogenesis, particularly those associated with metastasis.
Published Version: doi:10.1073/pnas.0712345105
Other Sources: http://www.ncbi.nlm.nih.gov/pubmed/18337506
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11644153
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