Evolutionary principles of modular gene regulation in yeasts

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Evolutionary principles of modular gene regulation in yeasts

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Title: Evolutionary principles of modular gene regulation in yeasts
Author: Thompson, Dawn A; Roy, Sushmita; Chan, Michelle; Styczynsky, Mark P; Pfiffner, Jenna; French, Courtney; Socha, Amanda; Thielke, Anne; Napolitano, Sara; Muller, Paul; Kellis, Manolis; Konieczka, Jay H; Wapinski, Ilan; Regev, Aviv

Note: Order does not necessarily reflect citation order of authors.

Citation: Thompson, D. A., S. Roy, M. Chan, M. P. Styczynsky, J. Pfiffner, C. French, A. Socha, et al. 2013. “Evolutionary principles of modular gene regulation in yeasts.” eLife 2 (1): e00603. doi:10.7554/eLife.00603. http://dx.doi.org/10.7554/eLife.00603.
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Abstract: Divergence in gene regulation can play a major role in evolution. Here, we used a phylogenetic framework to measure mRNA profiles in 15 yeast species from the phylum Ascomycota and reconstruct the evolution of their modular regulatory programs along a time course of growth on glucose over 1 billion years. We found that modules have diverged proportionally to phylogenetic distance, with prominent changes in gene regulation accompanying changes in lifestyle and ploidy, especially in carbon metabolism. Paralogs have significantly contributed to regulatory divergence, typically within a very short window from their duplication. Paralogs from a whole genome duplication (WGD) event have a uniquely substantial contribution that extends over a longer span. Similar patterns occur when considering the evolution of the heat shock regulatory program measured in eight of the species, suggesting that these are general evolutionary principles. DOI: http://dx.doi.org/10.7554/eLife.00603.001
Published Version: doi:10.7554/eLife.00603
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687341/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11708542
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