Evolutionary principles of modular gene regulation in yeasts

View/ Open
Author
Thompson, Dawn A
Roy, Sushmita
Styczynsky, Mark P
Pfiffner, Jenna
French, Courtney
Socha, Amanda
Thielke, Anne
Napolitano, Sara
Muller, Paul
Kellis, Manolis
Konieczka, Jay H
Regev, Aviv
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.7554/eLife.00603Metadata
Show full item recordCitation
Thompson, D. A., S. Roy, M. Chan, M. P. Styczynsky, J. Pfiffner, C. French, A. Socha, et al. 2013. “Evolutionary principles of modular gene regulation in yeasts.” eLife 2 (1): e00603. doi:10.7554/eLife.00603. http://dx.doi.org/10.7554/eLife.00603.Abstract
Divergence in gene regulation can play a major role in evolution. Here, we used a phylogenetic framework to measure mRNA profiles in 15 yeast species from the phylum Ascomycota and reconstruct the evolution of their modular regulatory programs along a time course of growth on glucose over 1 billion years. We found that modules have diverged proportionally to phylogenetic distance, with prominent changes in gene regulation accompanying changes in lifestyle and ploidy, especially in carbon metabolism. Paralogs have significantly contributed to regulatory divergence, typically within a very short window from their duplication. Paralogs from a whole genome duplication (WGD) event have a uniquely substantial contribution that extends over a longer span. Similar patterns occur when considering the evolution of the heat shock regulatory program measured in eight of the species, suggesting that these are general evolutionary principles. DOI: http://dx.doi.org/10.7554/eLife.00603.001Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687341/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11708542
Collections
- FAS Scholarly Articles [17845]
- HMS Scholarly Articles [17714]
Contact administrator regarding this item (to report mistakes or request changes)