Structural snapshots of the reaction coordinate for O-GlcNAc transferase

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Lazarus, Michael B.
Jiang, Jiaoyang
Gloster, Tracey M.
Zandberg, Wesley F.
Whitworth, Garrett E.
Vocadlo, David J.
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https://doi.org/10.1038/nchembio.1109Metadata
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Lazarus, Michael B., Jiaoyang Jiang, Tracey M. Gloster, Wesley F. Zandberg, Garrett E. Whitworth, David J. Vocadlo, and Suzanne Walker. 2012. “Structural snapshots of the reaction coordinate for O-GlcNAc transferase.” Nature chemical biology 8 (12): 966-968. doi:10.1038/nchembio.1109. http://dx.doi.org/10.1038/nchembio.1109.Abstract
Visualization of the reaction coordinate undertaken by glycosyltransferases has remained elusive, but is critical for understanding this important class of enzyme. Using substrates and substrate mimics, we describe structural snapshots of all species along the kinetic pathway for human O-GlcNAc transferase, an intracellular enzyme that catalyzes installation of a dynamic post-translational modification. The structures reveal key features of the mechanism and show that substrate participation is important during catalysis.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3508357/pdf/Terms of Use
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http://nrs.harvard.edu/urn-3:HUL.InstRepos:11708547
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