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dc.contributor.authorHaiman, Christopher A.en_US
dc.contributor.authorFesinmeyer, Megan D.en_US
dc.contributor.authorSpencer, Kylee L.en_US
dc.contributor.authorBůžková, Petraen_US
dc.contributor.authorVoruganti, V. Sarojaen_US
dc.contributor.authorWan, Peggyen_US
dc.contributor.authorHaessler, Jeffen_US
dc.contributor.authorFranceschini, Noraen_US
dc.contributor.authorMonroe, Kristine R.en_US
dc.contributor.authorHoward, Barbara V.en_US
dc.contributor.authorJackson, Rebecca D.en_US
dc.contributor.authorFlorez, Jose C.en_US
dc.contributor.authorKolonel, Laurence N.en_US
dc.contributor.authorBuyske, Stevenen_US
dc.contributor.authorGoodloe, Robert J.en_US
dc.contributor.authorLiu, Siminen_US
dc.contributor.authorManson, JoAnn E.en_US
dc.contributor.authorMeigs, James B.en_US
dc.contributor.authorWaters, Kevinen_US
dc.contributor.authorMukamal, Kenneth J.en_US
dc.contributor.authorPendergrass, Sarah A.en_US
dc.contributor.authorShrader, Peteren_US
dc.contributor.authorWilkens, Lynne R.en_US
dc.contributor.authorHindorff, Lucia A.en_US
dc.contributor.authorAmbite, Jose Luisen_US
dc.contributor.authorNorth, Kari E.en_US
dc.contributor.authorPeters, Ulrikeen_US
dc.contributor.authorCrawford, Dana C.en_US
dc.contributor.authorLe Marchand, Loicen_US
dc.contributor.authorPankow, James S.en_US
dc.date.accessioned2014-02-13T19:01:03Z
dc.date.issued2012en_US
dc.identifier.citationHaiman, C. A., M. D. Fesinmeyer, K. L. Spencer, P. Bůžková, V. S. Voruganti, P. Wan, J. Haessler, et al. 2012. “Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations: The Population Architecture using Genomics and Epidemiology (PAGE) Consortium.” Diabetes 61 (6): 1642-1647. doi:10.2337/db11-1296. http://dx.doi.org/10.2337/db11-1296.en
dc.identifier.issn0012-1797en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11708555
dc.description.abstractCommon genetic risk variants for type 2 diabetes (T2D) have primarily been identified in populations of European and Asian ancestry. We tested whether the direction of association with 20 T2D risk variants generalizes across six major racial/ethnic groups in the U.S. as part of the Population Architecture using Genomics and Epidemiology Consortium (16,235 diabetes case and 46,122 control subjects of European American, African American, Hispanic, East Asian, American Indian, and Native Hawaiian ancestry). The percentage of positive (odds ratio [OR] >1 for putative risk allele) associations ranged from 69% in American Indians to 100% in European Americans. Of the nine variants where we observed significant heterogeneity of effect by racial/ethnic group (Pheterogeneity < 0.05), eight were positively associated with risk (OR >1) in at least five groups. The marked directional consistency of association observed for most genetic variants across populations implies a shared functional common variant in each region. Fine-mapping of all loci will be required to reveal markers of risk that are important within and across populations.en
dc.language.isoen_USen
dc.publisherAmerican Diabetes Associationen
dc.relation.isversionofdoi:10.2337/db11-1296en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357304/pdf/en
dash.licenseLAAen_US
dc.titleConsistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations: The Population Architecture using Genomics and Epidemiology (PAGE) Consortiumen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalDiabetesen
dash.depositing.authorFlorez, Jose C.en_US
dc.date.available2014-02-13T19:01:03Z
dc.identifier.doi10.2337/db11-1296*
dash.authorsorderedfalse
dash.contributor.affiliatedManson, JoAnn
dash.contributor.affiliatedFlorez, Jose
dash.contributor.affiliatedMeigs, James


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