Early Nutrition and Weight Gain in Preterm Newborns and the Risk of Retinopathy of Prematurity

View/ Open
Author
Mehendale, Reshma
Dammann, Olaf
Published Version
https://doi.org/10.1371/journal.pone.0064325Metadata
Show full item recordCitation
VanderVeen, Deborah K., Camilia R. Martin, Reshma Mehendale, Elizabeth N. Allred, Olaf Dammann, and Alan Leviton. 2013. “Early Nutrition and Weight Gain in Preterm Newborns and the Risk of Retinopathy of Prematurity.” PLoS ONE 8 (5): e64325. doi:10.1371/journal.pone.0064325. http://dx.doi.org/10.1371/journal.pone.0064325.Abstract
Objective: To identify nutritional and weight gain limitations associated with retinopathy of prematurity (ROP) severity among very preterm newborns. Patients and Methods 1180 infants <28 weeks GA at birth with ROP examination results were grouped and analyzed by quartile of weekly total calorie, carbohydrate, protein, and lipid intake, as well as growth velocity between postnatal days 7 and 28 (adjusted for GA and birth weight Z-score). ROP was categorized by development of no, mild (<prethreshold), type 2, or type 1 ROP, as well as markers of ROP severity including stage 3 ROP, zone 1 disease, and plus disease. Associations between nutritional intake and ROP severity were compared. Results: Greater risk for Type 1 ROP (risk/95% confidence intervals) was found for infants with lowest quartile receipt of lipids (2.1/1.1, 3.8), total calories (2.2/1.4, 3.6), and carbohydrates (1.7/1.1, 2.9). Development of zone 1 ROP was associated with lipid or total calorie intake in the lowest quartile, and development of stage 3 ROP was associated with lowest quartile of total calorie intake. Growth velocity in the lowest quartile was associated with increased risk of any ROP, including type 1 ROP. Conclusion: The risk of developing severe ROP in extremely premature infants might be reduced by improving nutritional support, specifically targeting lipids and total calories, and perhaps by improving weight gain.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667175/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11708560
Collections
- HMS Scholarly Articles [17714]
- SPH Scholarly Articles [6329]
Contact administrator regarding this item (to report mistakes or request changes)