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dc.contributor.authorFortner, Renée Ten_US
dc.contributor.authorEliassen, A Heatheren_US
dc.contributor.authorSpiegelman, Donnaen_US
dc.contributor.authorWillett, Walter Cen_US
dc.contributor.authorBarbieri, Robert Len_US
dc.contributor.authorHankinson, Susan Een_US
dc.date.accessioned2014-02-13T19:01:09Z
dc.date.issued2013en_US
dc.identifier.citationFortner, Renée T, A Heather Eliassen, Donna Spiegelman, Walter C Willett, Robert L Barbieri, and Susan E Hankinson. 2013. “Premenopausal endogenous steroid hormones and breast cancer risk: results from the Nurses' Health Study II.” Breast Cancer Research : BCR 15 (2): R19. doi:10.1186/bcr3394. http://dx.doi.org/10.1186/bcr3394.en
dc.identifier.issn1465-5411en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11708570
dc.description.abstractIntroduction: Prior research supports an association between endogenous sex steroids and breast cancer among postmenopausal women; the association is less clear among premenopausal women. Methods: We evaluated the associations between estrogens, androgens, progesterone and sex hormone binding globulin (SHBG) and breast cancer in a nested case-control study in the Nurses' Health Study II. Between 1996 and 1999, 29,611 participants provided blood samples; 18,521 provided samples timed in early follicular and mid-luteal phases of the menstrual cycle. A total of 634 women, premenopausal at blood collection, developed breast cancer between 1999 and 2009 and were matched to 1,264 controls (514 cases and 1,030 controls with timed samples). We used conditional logistic regression controlling for breast cancer risk factors for overall analyses; unconditional logistic regression additionally controlling for matching factors was used for subgroup analyses. Results: In analyses of premenopausal estrogens including breast cancers diagnosed both before and after menopause, there was no association between follicular estradiol, estrone and free estradiol and risk of either total or invasive breast cancer. Luteal estradiol was positively associated with estrogen receptor positive (ER+)/progesterone receptor positive (PR+) cancers (5th vs. 1st quintile odds ratio (OR): 1.7 (95% confidence interval (CI): 1.0 to 2.9), Ptrend = 0.02). Luteal estrone, free estradiol and progesterone were not associated with risk. Androgens were suggestively or significantly associated with risk when the sample was restricted to invasive tumors (for example, testosterone: OR: 1.4 (1.0 to 2.0), Ptrend = 0.23) and ER+/PR+ disease (testosterone: OR: 1.7 (1.1 to 2.6) Ptrend = 0.10; dehydroepiandrosterone sulfate (DHEAS) OR: 1.3 (0.8 to 2.0) Ptrend = 0.05). SHBG was not associated with breast cancer risk. The results varied by menopausal status at diagnosis, with follicular estradiol suggestively positively associated with breast cancers in women premenopausal at diagnosis (OR: 1.1 (0.9 to 1.3) and significantly inversely associated with postmenopausal disease (OR: 0.6 (0.4 to 0.9); Pheterogeneity < 0.01). Conclusions: Androgens were associated with modestly increased risk of breast cancer in this population, with stronger associations for invasive and ER+/PR+ disease. Luteal phase estradiol levels were suggestively associated with ER+/PR+ tumors but no other strong associations were observed with estrogens. Associations with follicular phase estrogens may vary by menopausal status at diagnosis, but case numbers were limited. Additional studies to confirm the role of premenopausal hormones in the etiology of both premenopausal and postmenopausal breast cancer are needed.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/bcr3394en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672790/pdf/en
dash.licenseLAAen_US
dc.titlePremenopausal endogenous steroid hormones and breast cancer risk: results from the Nurses' Health Study IIen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBreast Cancer Research : BCRen
dash.depositing.authorEliassen, A Heatheren_US
dc.date.available2014-02-13T19:01:09Z
dc.identifier.doi10.1186/bcr3394*
dash.contributor.affiliatedEliassen, A.
dash.contributor.affiliatedWillett, Walter
dash.contributor.affiliatedHankinson, Susan
dash.contributor.affiliatedSpiegelman, Donna


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