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dc.contributor.authorAndrianaranjaka, Voahangyen_US
dc.contributor.authorLin, Jessica Ten_US
dc.contributor.authorGolden, Christopheren_US
dc.contributor.authorJuliano, Jonathan Jen_US
dc.contributor.authorRandrianarivelojosia, Milijaonaen_US
dc.date.accessioned2014-02-13T19:01:22Z
dc.date.issued2013en_US
dc.identifier.citationAndrianaranjaka, Voahangy, Jessica T Lin, Christopher Golden, Jonathan J Juliano, and Milijaona Randrianarivelojosia. 2013. “Activation of minority-variant Plasmodium vivax hypnozoites following artesunate + amodiaquine treatment in a 23-year old man with relapsing malaria in Antananarivo, Madagascar.” Malaria Journal 12 (1): 177. doi:10.1186/1475-2875-12-177. http://dx.doi.org/10.1186/1475-2875-12-177.en
dc.identifier.issn1475-2875en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11708590
dc.description.abstractIn endemic areas, Plasmodium vivax relapses are difficult to distinguish from new infections. Genotyping of patients who experience relapse after returning to a malaria-free area can be used to explore the nature of hypnozoite activation and relapse. This paper describes a person who developed P. vivax malaria for the first time after travelling to Boriziny in the malaria endemic coastal area of Madagascar, then suffered two P. vivax relapses 11 weeks and 21 weeks later despite remaining in Antananarivo in the malaria-free central highlands area. He was treated with the combination artesunate + amodiaquine according to the national malaria policy in Madagascar. Genotyping by PCR-RFLP at pvmsp-3α as well as pvmsp1 heteroduplex tracking assay (HTA) showed the same dominant genotype at each relapse. Multiple recurring minority variants were also detected at each relapse, highlighting the propensity for multiple hypnozoite clones to activate simultaneously to cause relapse.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/1475-2875-12-177en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671981/pdf/en
dash.licenseLAAen_US
dc.titleActivation of minority-variant Plasmodium vivax hypnozoites following artesunate + amodiaquine treatment in a 23-year old man with relapsing malaria in Antananarivo, Madagascaren
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalMalaria Journalen
dash.depositing.authorGolden, Christopheren_US
dc.date.available2014-02-13T19:01:22Z
dc.identifier.doi10.1186/1475-2875-12-177*
dash.contributor.affiliatedGolden, Christopher


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