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dc.contributor.authorHaider, Batool Aen_US
dc.contributor.authorOlofin, Ibironkeen_US
dc.contributor.authorWang, Molinen_US
dc.contributor.authorSpiegelman, Donnaen_US
dc.contributor.authorEzzati, Majiden_US
dc.contributor.authorFawzi, Wafaie Wen_US
dc.date.accessioned2014-02-13T19:01:29Z
dc.date.issued2013en_US
dc.identifier.citationHaider, Batool A, Ibironke Olofin, Molin Wang, Donna Spiegelman, Majid Ezzati, and Wafaie W Fawzi. 2013. “Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis.” BMJ : British Medical Journal 346 (1): f3443. doi:10.1136/bmj.f3443. http://dx.doi.org/10.1136/bmj.f3443.en
dc.identifier.issn0959-8138en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11708596
dc.description.abstractObjectives: To summarise evidence on the associations of maternal anaemia and prenatal iron use with maternal haematological and adverse pregnancy outcomes; and to evaluate potential exposure-response relations of dose of iron, duration of use, and haemoglobin concentration in prenatal period with pregnancy outcomes. Design: Systematic review and meta-analysis Data sources Searches of PubMed and Embase for studies published up to May 2012 and references of review articles. Study selection criteria Randomised trials of prenatal iron use and prospective cohort studies of prenatal anaemia; cross sectional and case-control studies were excluded. Results: 48 randomised trials (17 793 women) and 44 cohort studies (1 851 682 women) were included. Iron use increased maternal mean haemoglobin concentration by 4.59 (95% confidence interval 3.72 to 5.46) g/L compared with controls and significantly reduced the risk of anaemia (relative risk 0.50, 0.42 to 0.59), iron deficiency (0.59, 0.46 to 0.79), iron deficiency anaemia (0.40, 0.26 to 0.60), and low birth weight (0.81, 0.71 to 0.93). The effect of iron on preterm birth was not significant (relative risk 0.84, 0.68 to 1.03). Analysis of cohort studies showed a significantly higher risk of low birth weight (adjusted odds ratio 1.29, 1.09 to 1.53) and preterm birth (1.21, 1.13 to 1.30) with anaemia in the first or second trimester. Exposure-response analysis indicated that for every 10 mg increase in iron dose/day, up to 66 mg/day, the relative risk of maternal anaemia was 0.88 (0.84 to 0.92) (P for linear trend<0.001). Birth weight increased by 15.1 (6.0 to 24.2) g (P for linear trend=0.005) and risk of low birth weight decreased by 3% (relative risk 0.97, 0.95 to 0.98) for every 10 mg increase in dose/day (P for linear trend<0.001). Duration of use was not significantly associated with the outcomes after adjustment for dose. Furthermore, for each 1 g/L increase in mean haemoglobin, birth weight increased by 14.0 (6.8 to 21.8) g (P for linear trend=0.002); however, mean haemoglobin was not associated with the risk of low birth weight and preterm birth. No evidence of a significant effect on duration of gestation, small for gestational age births, and birth length was noted. Conclusions: Daily prenatal use of iron substantially improved birth weight in a linear dose-response fashion, probably leading to a reduction in risk of low birth weight. An improvement in prenatal mean haemoglobin concentration linearly increased birth weight.en
dc.language.isoen_USen
dc.publisherBMJ Publishing Group Ltd.en
dc.relation.isversionofdoi:10.1136/bmj.f3443en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689887/pdf/en
dash.licenseLAAen_US
dc.titleAnaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysisen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMJ : British Medical Journalen
dash.depositing.authorHaider, Batool Aen_US
dc.date.available2014-02-13T19:01:29Z
dc.identifier.doi10.1136/bmj.f3443*
dash.contributor.affiliatedHaider, Batool A
dash.contributor.affiliatedOlofin, Ibironke
dash.contributor.affiliatedWang, Molin
dash.contributor.affiliatedSpiegelman, Donna
dash.contributor.affiliatedFawzi, Wafaie
dc.identifier.orcid0000-0003-4006-4650
dc.identifier.orcid0000-0002-2908-600X


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