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dc.contributor.authorHoffmann, Christianen_US
dc.contributor.authorDollive, Serenaen_US
dc.contributor.authorGrunberg, Stephanieen_US
dc.contributor.authorChen, Junen_US
dc.contributor.authorLi, Hongzheen_US
dc.contributor.authorWu, Gary D.en_US
dc.contributor.authorLewis, James D.en_US
dc.contributor.authorBushman, Frederic D.en_US
dc.date.accessioned2014-02-13T19:01:35Z
dc.date.issued2013en_US
dc.identifier.citationHoffmann, Christian, Serena Dollive, Stephanie Grunberg, Jun Chen, Hongzhe Li, Gary D. Wu, James D. Lewis, and Frederic D. Bushman. 2013. “Archaea and Fungi of the Human Gut Microbiome: Correlations with Diet and Bacterial Residents.” PLoS ONE 8 (6): e66019. doi:10.1371/journal.pone.0066019. http://dx.doi.org/10.1371/journal.pone.0066019.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11708600
dc.description.abstractDiet influences health as a source of nutrients and toxins, and by shaping the composition of resident microbial populations. Previous studies have begun to map out associations between diet and the bacteria and viruses of the human gut microbiome. Here we investigate associations of diet with fungal and archaeal populations, taking advantage of samples from 98 well-characterized individuals. Diet was quantified using inventories scoring both long-term and recent diet, and archaea and fungi were characterized by deep sequencing of marker genes in DNA purified from stool. For fungi, we found 66 genera, with generally mutually exclusive presence of either the phyla Ascomycota or Basiodiomycota. For archaea, Methanobrevibacter was the most prevalent genus, present in 30% of samples. Several other archaeal genera were detected in lower abundance and frequency. Myriad associations were detected for fungi and archaea with diet, with each other, and with bacterial lineages. Methanobrevibacter and Candida were positively associated with diets high in carbohydrates, but negatively with diets high in amino acids, protein, and fatty acids. A previous study emphasized that bacterial population structure was associated primarily with long-term diet, but high Candida abundance was most strongly associated with the recent consumption of carbohydrates. Methobrevibacter abundance was associated with both long term and recent consumption of carbohydrates. These results confirm earlier targeted studies and provide a host of new associations to consider in modeling the effects of diet on the gut microbiome and human health.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0066019en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684604/pdf/en
dash.licenseLAAen_US
dc.subjectBiologyen
dc.subjectComputational Biologyen
dc.subjectSequence Analysisen
dc.subjectGenomicsen
dc.subjectMetagenomicsen
dc.subjectMicrobiologyen
dc.subjectMycologyen
dc.subjectFungien
dc.subjectArchaeansen
dc.subjectMicrobial Ecologyen
dc.subjectMicrobial Metabolismen
dc.subjectMedicineen
dc.subjectClinical Research Designen
dc.subjectCross-Sectional Studiesen
dc.subjectNutritionen
dc.subjectPediatricsen
dc.subjectNeonatologyen
dc.titleArchaea and Fungi of the Human Gut Microbiome: Correlations with Diet and Bacterial Residentsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorChen, Junen_US
dc.date.available2014-02-13T19:01:35Z
dc.identifier.doi10.1371/journal.pone.0066019*
dash.contributor.affiliatedChen, Jun


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