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dc.contributor.authorAhrens, Misha B.en_US
dc.contributor.authorHuang, Kuo Huaen_US
dc.contributor.authorNarayan, Sujathaen_US
dc.contributor.authorMensh, Brett D.en_US
dc.contributor.authorEngert, Florianen_US
dc.date.accessioned2014-02-13T19:01:38Z
dc.date.issued2013en_US
dc.identifier.citationAhrens, Misha B., Kuo Hua Huang, Sujatha Narayan, Brett D. Mensh, and Florian Engert. 2013. “Two-photon calcium imaging during fictive navigation in virtual environments.” Frontiers in Neural Circuits 7 (1): 104. doi:10.3389/fncir.2013.00104. http://dx.doi.org/10.3389/fncir.2013.00104.en
dc.identifier.issn1662-5110en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11708607
dc.description.abstractA full understanding of nervous system function requires recording from large populations of neurons during naturalistic behaviors. Here we enable paralyzed larval zebrafish to fictively navigate two-dimensional virtual environments while we record optically from many neurons with two-photon imaging. Electrical recordings from motor nerves in the tail are decoded into intended forward swims and turns, which are used to update a virtual environment displayed underneath the fish. Several behavioral features—such as turning responses to whole-field motion and dark avoidance—are well-replicated in this virtual setting. We readily observed neuronal populations in the hindbrain with laterally selective responses that correlated with right or left optomotor behavior. We also observed neurons in the habenula, pallium, and midbrain with response properties specific to environmental features. Beyond single-cell correlations, the classification of network activity in such virtual settings promises to reveal principles of brainwide neural dynamics during behavior.en
dc.language.isoen_USen
dc.publisherFrontiers Media S.A.en
dc.relation.isversionofdoi:10.3389/fncir.2013.00104en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674334/pdf/en
dash.licenseLAAen_US
dc.subjectMethods Articleen
dc.subjectzebrafishen
dc.subjectvirtual realityen
dc.subjecttwo-photon calcium imagingen
dc.subjectbehavioren
dc.subjectsensorimotor transformationsen
dc.subjectmotor controlen
dc.titleTwo-photon calcium imaging during fictive navigation in virtual environmentsen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalFrontiers in Neural Circuitsen
dash.depositing.authorEngert, Florianen_US
dc.date.available2014-02-13T19:01:38Z
dc.identifier.doi10.3389/fncir.2013.00104*
dash.contributor.affiliatedEngert, Florian


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