Distinctive Expansion of Potential Virulence Genes in the Genome of the Oomycete Fish Pathogen Saprolegnia parasitica

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Distinctive Expansion of Potential Virulence Genes in the Genome of the Oomycete Fish Pathogen Saprolegnia parasitica

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dc.contributor.author Jiang, Rays H. Y. en_US
dc.contributor.author de Bruijn, Irene en_US
dc.contributor.author Haas, Brian J. en_US
dc.contributor.author Belmonte, Rodrigo en_US
dc.contributor.author Löbach, Lars en_US
dc.contributor.author Christie, James en_US
dc.contributor.author van den Ackerveken, Guido en_US
dc.contributor.author Bottin, Arnaud en_US
dc.contributor.author Bulone, Vincent en_US
dc.contributor.author Díaz-Moreno, Sara M. en_US
dc.contributor.author Dumas, Bernard en_US
dc.contributor.author Fan, Lin en_US
dc.contributor.author Gaulin, Elodie en_US
dc.contributor.author Govers, Francine en_US
dc.contributor.author Grenville-Briggs, Laura J. en_US
dc.contributor.author Horner, Neil R. en_US
dc.contributor.author Levin, Joshua Z. en_US
dc.contributor.author Mammella, Marco en_US
dc.contributor.author Meijer, Harold J. G. en_US
dc.contributor.author Morris, Paul en_US
dc.contributor.author Nusbaum, Chad en_US
dc.contributor.author Oome, Stan en_US
dc.contributor.author Phillips, Andrew J. en_US
dc.contributor.author van Rooyen, David en_US
dc.contributor.author Rzeszutek, Elzbieta en_US
dc.contributor.author Saraiva, Marcia en_US
dc.contributor.author Secombes, Chris J. en_US
dc.contributor.author Seidl, Michael F. en_US
dc.contributor.author Snel, Berend en_US
dc.contributor.author Stassen, Joost H. M. en_US
dc.contributor.author Sykes, Sean en_US
dc.contributor.author Tripathy, Sucheta en_US
dc.contributor.author van den Berg, Herbert en_US
dc.contributor.author Vega-Arreguin, Julio C. en_US
dc.contributor.author Wawra, Stephan en_US
dc.contributor.author Young, Sarah K. en_US
dc.contributor.author Zeng, Qiandong en_US
dc.contributor.author Dieguez-Uribeondo, Javier en_US
dc.contributor.author Russ, Carsten en_US
dc.contributor.author Tyler, Brett M. en_US
dc.contributor.author van West, Pieter en_US
dc.date.accessioned 2014-02-13T19:01:43Z
dc.date.issued 2013 en_US
dc.identifier.citation Jiang, R. H. Y., I. de Bruijn, B. J. Haas, R. Belmonte, L. Löbach, J. Christie, G. van den Ackerveken, et al. 2013. “Distinctive Expansion of Potential Virulence Genes in the Genome of the Oomycete Fish Pathogen Saprolegnia parasitica.” PLoS Genetics 9 (6): e1003272. doi:10.1371/journal.pgen.1003272. http://dx.doi.org/10.1371/journal.pgen.1003272. en
dc.identifier.issn 1553-7390 en
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:11708611
dc.description.abstract Oomycetes in the class Saprolegniomycetidae of the Eukaryotic kingdom Stramenopila have evolved as severe pathogens of amphibians, crustaceans, fish and insects, resulting in major losses in aquaculture and damage to aquatic ecosystems. We have sequenced the 63 Mb genome of the fresh water fish pathogen, Saprolegnia parasitica. Approximately 1/3 of the assembled genome exhibits loss of heterozygosity, indicating an efficient mechanism for revealing new variation. Comparison of S. parasitica with plant pathogenic oomycetes suggests that during evolution the host cellular environment has driven distinct patterns of gene expansion and loss in the genomes of plant and animal pathogens. S. parasitica possesses one of the largest repertoires of proteases (270) among eukaryotes that are deployed in waves at different points during infection as determined from RNA-Seq data. In contrast, despite being capable of living saprotrophically, parasitism has led to loss of inorganic nitrogen and sulfur assimilation pathways, strikingly similar to losses in obligate plant pathogenic oomycetes and fungi. The large gene families that are hallmarks of plant pathogenic oomycetes such as Phytophthora appear to be lacking in S. parasitica, including those encoding RXLR effectors, Crinkler's, and Necrosis Inducing-Like Proteins (NLP). S. parasitica also has a very large kinome of 543 kinases, 10% of which is induced upon infection. Moreover, S. parasitica encodes several genes typical of animals or animal-pathogens and lacking from other oomycetes, including disintegrins and galactose-binding lectins, whose expression and evolutionary origins implicate horizontal gene transfer in the evolution of animal pathogenesis in S. parasitica. en
dc.language.iso en_US en
dc.publisher Public Library of Science en
dc.relation.isversionof doi:10.1371/journal.pgen.1003272 en
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681718/pdf/ en
dash.license LAA en_US
dc.subject Biology en
dc.subject Genomics en
dc.subject Comparative Genomics en
dc.subject Genome Databases en
dc.subject Genome Expression Analysis en
dc.subject Genome Sequencing en
dc.subject Microbiology en
dc.subject Emerging Infectious Diseases en
dc.subject Host-Pathogen Interaction en
dc.subject Microbial Pathogens en
dc.subject Parasitology en
dc.subject Pathogenesis en
dc.title Distinctive Expansion of Potential Virulence Genes in the Genome of the Oomycete Fish Pathogen Saprolegnia parasitica en
dc.type Journal Article en_US
dc.description.version Version of Record en
dc.relation.journal PLoS Genetics en
dash.depositing.author Levin, Joshua Z. en_US
dc.date.available 2014-02-13T19:01:43Z

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