Cortical synaptogenesis and excitatory synapse number are determined via a Neuroligin-1-dependent intercellular competition

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Cortical synaptogenesis and excitatory synapse number are determined via a Neuroligin-1-dependent intercellular competition

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Title: Cortical synaptogenesis and excitatory synapse number are determined via a Neuroligin-1-dependent intercellular competition
Author: Kwon, Hyung-Bae; Kozorovitskiy, Yevgenia; Oh, Won-Jong; Peixoto, Rui T.; Akhtar, Nazia; Saulnier, Jessica L.; Gu, Chenghua; Sabatini, Bernardo L.

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Citation: Kwon, Hyung-Bae, Yevgenia Kozorovitskiy, Won-Jong Oh, Rui T. Peixoto, Nazia Akhtar, Jessica L. Saulnier, Chenghua Gu, and Bernardo L. Sabatini. 2012. “Cortical synaptogenesis and excitatory synapse number are determined via a Neuroligin-1-dependent intercellular competition.” Nature neuroscience 15 (12): 1667-1674. doi:10.1038/nn.3256. http://dx.doi.org/10.1038/nn.3256.
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Abstract: Members of the neuroligin (NL) family of cell-adhesion proteins are found at excitatory and inhibitory synapses and are mutated in some familial forms of autism spectrum disorders. Although they display synaptogenic properties in heterologous systems, a function of NLs in vivo in regulating synapse formation and synapse number has been difficult to establish. Here we show that neuroligin-1 (NL1), which is located at excitatory post-synaptic densities, does regulate activity-dependent synaptogenesis as well as mature synapse number on cortical layer 2/3 pyramidal neurons in vivo. However, synapse number is not sensitive to absolute NL1 levels but rather to transcellular differences in the relative amounts of NL1. These effects are independent of the cell-autonomous regulation of NMDA-type glutamate receptors by absolute levels of NL1. Our data indicate that transcellular competitive processes govern synapse formation and number in developing cortex and that NL1 plays a central function in these processes.
Published Version: doi:10.1038/nn.3256
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536444/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11708638
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