On the near-wall accumulation of injectable particles in the microcirculation: smaller is not better

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On the near-wall accumulation of injectable particles in the microcirculation: smaller is not better

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Title: On the near-wall accumulation of injectable particles in the microcirculation: smaller is not better
Author: Lee, Tae-Rin; Choi, Myunghwan; Kopacz, Adrian M.; Yun, Seok-Hyun; Liu, Wing Kam; Decuzzi, Paolo

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Citation: Lee, Tae-Rin, Myunghwan Choi, Adrian M. Kopacz, Seok-Hyun Yun, Wing Kam Liu, and Paolo Decuzzi. 2013. “On the near-wall accumulation of injectable particles in the microcirculation: smaller is not better.” Scientific Reports 3 (1): 2079. doi:10.1038/srep02079. http://dx.doi.org/10.1038/srep02079.
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Abstract: Although most nanofabrication techniques can control nano/micro particle (NMP) size over a wide range, the majority of NMPs for biomedical applications exhibits a diameter of ~100 nm. Here, the vascular distribution of spherical particles, from 10 to 1,000 nm in diameter, is studied using intravital microscopy and computational modeling. Small NMPs (≤100 nm) are observed to move with Red Blood Cells (RBCs), presenting an uniform radial distribution and limited near-wall accumulation. Larger NMPs tend to preferentially accumulate next to the vessel walls, in a size-dependent manner (~70% for 1,000 nm NMPs). RBC-NMP geometrical interference only is responsible for this behavior. In a capillary flow, the effective radial dispersion coefficient of 1,000 nm particles is ~3-fold larger than Brownian diffusion. This suggests that sub-micron particles could deposit within diseased vascular districts more efficiently than conventional nanoparticles.
Published Version: doi:10.1038/srep02079
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693098/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11708641
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