Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy
Alvarez-Breckenridge, Christopher A.
Caligiuri, Michael A.
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CitationAlvarez-Breckenridge, Christopher A., Jianhua Yu, Michael A. Caligiuri, and E. Antonio Chiocca. 2013. “Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy.” Oncoimmunology 2 (4): e23658. doi:10.4161/onci.23658. http://dx.doi.org/10.4161/onci.23658.
AbstractDespite initial promising results, the success of clinical trials testing oncolytic viruses in glioblastoma patients has been limited. Innate immunity appears to be one among several barriers against successful viral oncolysis. Recent findings suggest a mechanism by which natural killer cells limit the efficacy of oncolytic viruses via natural cytotoxicity receptors.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11708645
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