Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy

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Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy

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Title: Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy
Author: Alvarez-Breckenridge, Christopher A.; Yu, Jianhua; Caligiuri, Michael A.; Chiocca, E. Antonio

Note: Order does not necessarily reflect citation order of authors.

Citation: Alvarez-Breckenridge, Christopher A., Jianhua Yu, Michael A. Caligiuri, and E. Antonio Chiocca. 2013. “Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy.” Oncoimmunology 2 (4): e23658. doi:10.4161/onci.23658. http://dx.doi.org/10.4161/onci.23658.
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Abstract: Despite initial promising results, the success of clinical trials testing oncolytic viruses in glioblastoma patients has been limited. Innate immunity appears to be one among several barriers against successful viral oncolysis. Recent findings suggest a mechanism by which natural killer cells limit the efficacy of oncolytic viruses via natural cytotoxicity receptors.
Published Version: doi:10.4161/onci.23658
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654589/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11708645
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