Neural population partitioning and a concurrent brain-machine interface for sequential motor function
View/ Open
Author
Shanechi, Maryam M.
Hu, Rollin C.
Powers, Marissa
Wornell, Gregory W.
Williams, Ziv M.
Published Version
https://doi.org/10.1038/nn.3250Metadata
Show full item recordCitation
Shanechi, Maryam M., Rollin C. Hu, Marissa Powers, Gregory W. Wornell, Emery N. Brown, and Ziv M. Williams. 2012. “Neural population partitioning and a concurrent brain-machine interface for sequential motor function.” Nature neuroscience 15 (12): 10.1038/nn.3250. doi:10.1038/nn.3250. http://dx.doi.org/10.1038/nn.3250.Abstract
While brain-machine interfaces (BMIs) have largely focused on performing single-targeted movements, many natural tasks involve planning a complete sequence of such movements before execution. For these tasks, a BMI that can concurrently decode the full planned sequence prior to its execution may also consider the higher-level goal of the task to reformulate and perform it more effectively. Here, we show that concurrent BMI decoding is possible. Using population-wide modeling, we discover two distinct subpopulations of neurons in the rhesus monkey premotor cortex that allow two planned targets of a sequential movement to be simultaneously held in working memory without degradation. Such surprising stability occurred because each subpopulation encoded either only currently held or only newly added target information irrespective of the exact sequence. Based on these findings, we develop a BMI that concurrently decodes a full motor sequence in advance of movement and then can accurately execute it as desired.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509235/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11708656
Collections
- HMS Scholarly Articles [17922]
Contact administrator regarding this item (to report mistakes or request changes)