Role of Murine Intestinal Interleukin-1 Receptor 1-Expressing Lymphoid Tissue Inducer-Like Cells in Salmonella Infection
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Role of Murine Intestinal Interleukin-1 Receptor 1-Expressing Lymphoid Tissue Inducer-Like Cells in Salmonella Infection
| Title: | Role of Murine Intestinal Interleukin-1 Receptor 1-Expressing Lymphoid Tissue Inducer-Like Cells in Salmonella Infection |
| Author: |
Chen, Vincent L.; Surana, Neeraj K.; Duan, Jinyou; Kasper, Dennis L.
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Chen, Vincent L., Neeraj K. Surana, Jinyou Duan, and Dennis L. Kasper. 2013. “Role of Murine Intestinal Interleukin-1 Receptor 1-Expressing Lymphoid Tissue Inducer-Like Cells in Salmonella Infection.” PLoS ONE 8 (6): e65405. doi:10.1371/journal.pone.0065405. http://dx.doi.org/10.1371/journal.pone.0065405. |
| Full Text & Related Files: |
3672157.pdf (796.8Kb; PDF) 
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| Abstract: | Interleukin (IL)-1 signaling plays a critical role in intestinal immunology. Here, we report that the major population of intestinal lamina propria lymphocytes expressing IL-1 receptor 1 (IL-1R1) is the lymphoid tissue inducer (LTi)-like cell, a type of innate lymphoid cell. These cells are significant producers of IL-22, and this IL-22 production depends on IL-1R1 signaling. LTi-like cells are required for defense against Salmonella enterica serovar Typhimurium. Moreover, colonic LTi-like cell numbers depend on the presence of the intestinal microbiota. LTi-like cells require IL-1R1 for production of protective cytokines and confer protection in infectious colitis, and their cell numbers in the colon depend upon having a microbiome. |
| Published Version: | doi:10.1371/journal.pone.0065405 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672157/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11708661 |
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