Linking abnormal mitosis to the acquisition of DNA damage

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Linking abnormal mitosis to the acquisition of DNA damage

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Title: Linking abnormal mitosis to the acquisition of DNA damage
Author: Ganem, Neil J.; Pellman, David

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Citation: Ganem, Neil J., and David Pellman. 2012. “Linking abnormal mitosis to the acquisition of DNA damage.” The Journal of Cell Biology 199 (6): 871-881. doi:10.1083/jcb.201210040. http://dx.doi.org/10.1083/jcb.201210040.
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Abstract: Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct and indirect acquisition of DNA damage and chromosome breaks. Consequently, deregulated cell division can devastate the integrity of the normal genome and unleash a variety of oncogenic stimuli that may promote transformation. Recent work has shed light on the mechanisms that link abnormal mitosis with the development of DNA damage, how cells respond to such affronts, and the potential impact on tumorigenesis.
Published Version: doi:10.1083/jcb.201210040
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518222/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11708674
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