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dc.contributor.authorEames, B Franken_US
dc.contributor.authorDeLaurier, Aprilen_US
dc.contributor.authorUllmann, Bonnieen_US
dc.contributor.authorHuycke, Tyler Ren_US
dc.contributor.authorNichols, James Ten_US
dc.contributor.authorDowd, Johnen_US
dc.contributor.authorMcFadden, Marcieen_US
dc.contributor.authorSasaki, Mark Men_US
dc.contributor.authorKimmel, Charles Ben_US
dc.date.accessioned2014-02-18T18:10:29Z
dc.date.issued2013en_US
dc.identifier.citationEames, B Frank, April DeLaurier, Bonnie Ullmann, Tyler R Huycke, James T Nichols, John Dowd, Marcie McFadden, Mark M Sasaki, and Charles B Kimmel. 2013. “FishFace: interactive atlas of zebrafish craniofacial development at cellular resolution.” BMC Developmental Biology 13 (1): 23. doi:10.1186/1471-213X-13-23. http://dx.doi.org/10.1186/1471-213X-13-23.en
dc.identifier.issn1471-213Xen
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11717496
dc.description.abstractBackground: The vertebrate craniofacial skeleton may exhibit anatomical complexity and diversity, but its genesis and evolution can be understood through careful dissection of developmental programs at cellular resolution. Resources are lacking that include introductory overviews of skeletal anatomy coupled with descriptions of craniofacial development at cellular resolution. In addition to providing analytical guidelines for other studies, such an atlas would suggest cellular mechanisms underlying development. Description We present the Fish Face Atlas, an online, 3D-interactive atlas of craniofacial development in the zebrafish Danio rerio. Alizarin red-stained skulls scanned by fluorescent optical projection tomography and segmented into individual elements provide a resource for understanding the 3D structure of the zebrafish craniofacial skeleton. These data provide the user an anatomical entry point to confocal images of Alizarin red-stained zebrafish with transgenically-labelled pharyngeal arch ectomesenchyme, chondrocytes, and osteoblasts, which illustrate the appearance, morphogenesis, and growth of the mandibular and hyoid cartilages and bones, as viewed in live, anesthetized zebrafish during embryonic and larval development. Confocal image stacks at high magnification during the same stages provide cellular detail and suggest developmental and evolutionary hypotheses. Conclusion: The FishFace Atlas is a novel learning tool for understanding craniofacial skeletal development, and can serve as a reference for a variety of studies, including comparative and mutational analyses.en
dc.language.isoen_USen
dc.publisherBioMed Centralen
dc.relation.isversionofdoi:10.1186/1471-213X-13-23en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3698193/pdf/en
dash.licenseLAAen_US
dc.subjectCraniofacial developmenten
dc.subjectWebsite atlasen
dc.subjectZebrafishen
dc.subjectBoneen
dc.subjectCartilageen
dc.subjectSkeletonen
dc.subjectEvolutionen
dc.titleFishFace: interactive atlas of zebrafish craniofacial development at cellular resolutionen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMC Developmental Biologyen
dash.depositing.authorHuycke, Tyler Ren_US
dc.date.available2014-02-18T18:10:29Z
dc.identifier.doi10.1186/1471-213X-13-23*
dash.contributor.affiliatedHuycke, Tyler


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