Criteria for assessing high-priority drug-drug interactions for clinical decision support in electronic health records

DSpace/Manakin Repository

Criteria for assessing high-priority drug-drug interactions for clinical decision support in electronic health records

Citable link to this page

 

 
Title: Criteria for assessing high-priority drug-drug interactions for clinical decision support in electronic health records
Author: Phansalkar, Shobha; Desai, Amrita; Choksi, Anish; Yoshida, Eileen; Doole, John; Czochanski, Melissa; Tucker, Alisha D; Middleton, Blackford; Bell, Douglas; Bates, David W

Note: Order does not necessarily reflect citation order of authors.

Citation: Phansalkar, Shobha, Amrita Desai, Anish Choksi, Eileen Yoshida, John Doole, Melissa Czochanski, Alisha D Tucker, Blackford Middleton, Douglas Bell, and David W Bates. 2013. “Criteria for assessing high-priority drug-drug interactions for clinical decision support in electronic health records.” BMC Medical Informatics and Decision Making 13 (1): 65. doi:10.1186/1472-6947-13-65. http://dx.doi.org/10.1186/1472-6947-13-65.
Full Text & Related Files:
Abstract: Background: High override rates for drug-drug interaction (DDI) alerts in electronic health records (EHRs) result in the potentially dangerous consequence of providers ignoring clinically significant alerts. Lack of uniformity of criteria for determining the severity or validity of these interactions often results in discrepancies in how these are evaluated. The purpose of this study was to identify a set of criteria for assessing DDIs that should be used for the generation of clinical decision support (CDS) alerts in EHRs. Methods: We conducted a 20-year systematic literature review of MEDLINE and EMBASE to identify characteristics of high-priority DDIs. These criteria were validated by an expert panel consisting of medication knowledge base vendors, EHR vendors, in-house knowledge base developers from academic medical centers, and both federal and private agencies involved in the regulation of medication use. Results: Forty-four articles met the inclusion criteria for assessing characteristics of high-priority DDIs. The panel considered five criteria to be most important when assessing an interaction- Severity, Probability, Clinical Implications of the interaction, Patient characteristics, and the Evidence supporting the interaction. In addition, the panel identified barriers and considerations for being able to utilize these criteria in medication knowledge bases used by EHRs. Conclusions: A multi-dimensional approach is needed to understanding the importance of an interaction for inclusion in medication knowledge bases for the purpose of CDS alerting. The criteria identified in this study can serve as a first step towards a uniform approach in assessing which interactions are critical and warrant interruption of a provider’s workflow.
Published Version: doi:10.1186/1472-6947-13-65
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706355/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11717506
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters