HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection
MacLeod, Daniel T.
Gallo, Richard L.
MetadataShow full item record
CitationMacLeod, Daniel T., Teruaki Nakatsuji, Kenshi Yamasaki, Lester Kobzik, and Richard L. Gallo. 2013. “HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection.” Nature communications 4 (1): 1963. doi:10.1038/ncomms2963. http://dx.doi.org/10.1038/ncomms2963.
AbstractHSV-1 is an important epithelial pathogen and has the potential for significant morbidity in humans. Here we demonstrate that a cell surface scavenger receptor, macrophage receptor with collagenous structure (MARCO), previously thought to enhance antiviral defense by enabling nucleic acid recognition, is usurped by HSV-1 and functions together with heparan sulfate proteoglycans to mediate adsorption to epithelial cells. Ligands of MARCO dramatically inhibit HSV-1 adsorption and infection of human keratinocytes and protect mice against infection. HSV-1 glycoprotein C (gC) closely co-localizes with MARCO at the cell surface, and gC binds directly to purified MARCO with high affinity. Increasing MARCO expression enhances HSV-1 infection while MARCO-/- mice have reduced susceptibility to infection by HSV-1. These findings demonstrate that HSV-1 binds to MARCO to enhance its capacity for disease, and suggests a new therapeutic target to alter pathogenicity of HSV-1 in skin infection.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11717518