HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection

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HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection

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Title: HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection
Author: MacLeod, Daniel T.; Nakatsuji, Teruaki; Yamasaki, Kenshi; Kobzik, Lester; Gallo, Richard L.

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Citation: MacLeod, Daniel T., Teruaki Nakatsuji, Kenshi Yamasaki, Lester Kobzik, and Richard L. Gallo. 2013. “HSV-1 exploits the innate immune scavenger receptor MARCO to enhance epithelial adsorption and infection.” Nature communications 4 (1): 1963. doi:10.1038/ncomms2963. http://dx.doi.org/10.1038/ncomms2963.
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Abstract: HSV-1 is an important epithelial pathogen and has the potential for significant morbidity in humans. Here we demonstrate that a cell surface scavenger receptor, macrophage receptor with collagenous structure (MARCO), previously thought to enhance antiviral defense by enabling nucleic acid recognition, is usurped by HSV-1 and functions together with heparan sulfate proteoglycans to mediate adsorption to epithelial cells. Ligands of MARCO dramatically inhibit HSV-1 adsorption and infection of human keratinocytes and protect mice against infection. HSV-1 glycoprotein C (gC) closely co-localizes with MARCO at the cell surface, and gC binds directly to purified MARCO with high affinity. Increasing MARCO expression enhances HSV-1 infection while MARCO-/- mice have reduced susceptibility to infection by HSV-1. These findings demonstrate that HSV-1 binds to MARCO to enhance its capacity for disease, and suggests a new therapeutic target to alter pathogenicity of HSV-1 in skin infection.
Published Version: doi:10.1038/ncomms2963
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3681428/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11717518
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