Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report

View/ Open
Author
Manchia, Mirko
Adli, Mazda
Akula, Nirmala
Ardau, Raffaella
Aubry, Jean-Michel
Backlund, Lena
Banzato, Claudio EM.
Baune, Bernhard T.
Bellivier, Frank
Bengesser, Susanne
Biernacka, Joanna M.
Brichant-Petitjean, Clara
Bui, Elise
Calkin, Cynthia V.
Cheng, Andrew Tai Ann
Chillotti, Caterina
Cichon, Sven
Clark, Scott
Czerski, Piotr M.
Dantas, Clarissa
Zompo, Maria Del
DePaulo, J. Raymond
Detera-Wadleigh, Sevilla D.
Etain, Bruno
Falkai, Peter
Frisén, Louise
Frye, Mark A.
Fullerton, Jan
Gard, Sébastien
Garnham, Julie
Goes, Fernando S.
Grof, Paul
Gruber, Oliver
Hashimoto, Ryota
Hauser, Joanna
Heilbronner, Urs
Hoban, Rebecca
Hou, Liping
Jamain, Stéphane
Kahn, Jean-Pierre
Kassem, Layla
Kato, Tadafumi
Kelsoe, John R.
Kittel-Schneider, Sarah
Kliwicki, Sebastian
Kuo, Po-Hsiu
Kusumi, Ichiro
Laje, Gonzalo
Lavebratt, Catharina
Leboyer, Marion
Leckband, Susan G.
López Jaramillo, Carlos A.
Maj, Mario
Malafosse, Alain
Martinsson, Lina
Masui, Takuya
Mitchell, Philip B.
Mondimore, Frank
Monteleone, Palmiero
Nallet, Audrey
Neuner, Maria
Novák, Tomás
O’Donovan, Claire
Ösby, Urban
Ozaki, Norio
Pfennig, Andrea
Potash, James B.
Reich-Erkelenz, Daniela
Reif, Andreas
Reininghaus, Eva
Richardson, Sara
Rouleau, Guy A.
Rybakowski, Janusz K.
Schalling, Martin
Schofield, Peter R.
Schubert, Oliver K.
Schweizer, Barbara
Seemüller, Florian
Grigoroiu-Serbanescu, Maria
Severino, Giovanni
Seymour, Lisa R.
Slaney, Claire
Squassina, Alessio
Stamm, Thomas
Steele, Jo
Stopkova, Pavla
Tighe, Sarah K.
Tortorella, Alfonso
Turecki, Gustavo
Wray, Naomi R.
Wright, Adam
Zandi, Peter P.
Zilles, David
Bauer, Michael
Rietschel, Marcella
McMahon, Francis J.
Schulze, Thomas G.
Alda, Martin
Note: Order does not necessarily reflect citation order of authors.
Published Version
https://doi.org/10.1371/journal.pone.0065636Metadata
Show full item recordCitation
Manchia, M., M. Adli, N. Akula, R. Ardau, J. Aubry, L. Backlund, C. E. Banzato, et al. 2013. “Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report.” PLoS ONE 8 (6): e65636. doi:10.1371/journal.pone.0065636. http://dx.doi.org/10.1371/journal.pone.0065636.Abstract
Objective: The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the “Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder” scale currently used in the Consortium on Lithium Genetics (ConLiGen) study. Materials and Methods Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (κ)] and reliability [intra-class correlation coefficient (ICC)] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling. Results: Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (κ = 0.66 and κ = 0.54, respectively), without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (ICC1 = 0.71 and ICC2 = 0.75, respectively). Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders). Conclusions: We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686769/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11717519
Collections
- HMS Scholarly Articles [17714]
- SPH Scholarly Articles [6329]
Contact administrator regarding this item (to report mistakes or request changes)