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dc.contributor.authorManchia, Mirkoen_US
dc.contributor.authorAdli, Mazdaen_US
dc.contributor.authorAkula, Nirmalaen_US
dc.contributor.authorArdau, Raffaellaen_US
dc.contributor.authorAubry, Jean-Michelen_US
dc.contributor.authorBacklund, Lenaen_US
dc.contributor.authorBanzato, Claudio EM.en_US
dc.contributor.authorBaune, Bernhard T.en_US
dc.contributor.authorBellivier, Franken_US
dc.contributor.authorBengesser, Susanneen_US
dc.contributor.authorBiernacka, Joanna M.en_US
dc.contributor.authorBrichant-Petitjean, Claraen_US
dc.contributor.authorBui, Eliseen_US
dc.contributor.authorCalkin, Cynthia V.en_US
dc.contributor.authorCheng, Andrew Tai Annen_US
dc.contributor.authorChillotti, Caterinaen_US
dc.contributor.authorCichon, Svenen_US
dc.contributor.authorClark, Scotten_US
dc.contributor.authorCzerski, Piotr M.en_US
dc.contributor.authorDantas, Clarissaen_US
dc.contributor.authorZompo, Maria Delen_US
dc.contributor.authorDePaulo, J. Raymonden_US
dc.contributor.authorDetera-Wadleigh, Sevilla D.en_US
dc.contributor.authorEtain, Brunoen_US
dc.contributor.authorFalkai, Peteren_US
dc.contributor.authorFrisén, Louiseen_US
dc.contributor.authorFrye, Mark A.en_US
dc.contributor.authorFullerton, Janen_US
dc.contributor.authorGard, Sébastienen_US
dc.contributor.authorGarnham, Julieen_US
dc.contributor.authorGoes, Fernando S.en_US
dc.contributor.authorGrof, Paulen_US
dc.contributor.authorGruber, Oliveren_US
dc.contributor.authorHashimoto, Ryotaen_US
dc.contributor.authorHauser, Joannaen_US
dc.contributor.authorHeilbronner, Ursen_US
dc.contributor.authorHoban, Rebeccaen_US
dc.contributor.authorHou, Lipingen_US
dc.contributor.authorJamain, Stéphaneen_US
dc.contributor.authorKahn, Jean-Pierreen_US
dc.contributor.authorKassem, Laylaen_US
dc.contributor.authorKato, Tadafumien_US
dc.contributor.authorKelsoe, John R.en_US
dc.contributor.authorKittel-Schneider, Sarahen_US
dc.contributor.authorKliwicki, Sebastianen_US
dc.contributor.authorKuo, Po-Hsiuen_US
dc.contributor.authorKusumi, Ichiroen_US
dc.contributor.authorLaje, Gonzaloen_US
dc.contributor.authorLavebratt, Catharinaen_US
dc.contributor.authorLeboyer, Marionen_US
dc.contributor.authorLeckband, Susan G.en_US
dc.contributor.authorLópez Jaramillo, Carlos A.en_US
dc.contributor.authorMaj, Marioen_US
dc.contributor.authorMalafosse, Alainen_US
dc.contributor.authorMartinsson, Linaen_US
dc.contributor.authorMasui, Takuyaen_US
dc.contributor.authorMitchell, Philip B.en_US
dc.contributor.authorMondimore, Franken_US
dc.contributor.authorMonteleone, Palmieroen_US
dc.contributor.authorNallet, Audreyen_US
dc.contributor.authorNeuner, Mariaen_US
dc.contributor.authorNovák, Tomásen_US
dc.contributor.authorO’Donovan, Claireen_US
dc.contributor.authorÖsby, Urbanen_US
dc.contributor.authorOzaki, Norioen_US
dc.contributor.authorPerlis, Roy H.en_US
dc.contributor.authorPfennig, Andreaen_US
dc.contributor.authorPotash, James B.en_US
dc.contributor.authorReich-Erkelenz, Danielaen_US
dc.contributor.authorReif, Andreasen_US
dc.contributor.authorReininghaus, Evaen_US
dc.contributor.authorRichardson, Saraen_US
dc.contributor.authorRouleau, Guy A.en_US
dc.contributor.authorRybakowski, Janusz K.en_US
dc.contributor.authorSchalling, Martinen_US
dc.contributor.authorSchofield, Peter R.en_US
dc.contributor.authorSchubert, Oliver K.en_US
dc.contributor.authorSchweizer, Barbaraen_US
dc.contributor.authorSeemüller, Florianen_US
dc.contributor.authorGrigoroiu-Serbanescu, Mariaen_US
dc.contributor.authorSeverino, Giovannien_US
dc.contributor.authorSeymour, Lisa R.en_US
dc.contributor.authorSlaney, Claireen_US
dc.contributor.authorSmoller, Jordan W.en_US
dc.contributor.authorSquassina, Alessioen_US
dc.contributor.authorStamm, Thomasen_US
dc.contributor.authorSteele, Joen_US
dc.contributor.authorStopkova, Pavlaen_US
dc.contributor.authorTighe, Sarah K.en_US
dc.contributor.authorTortorella, Alfonsoen_US
dc.contributor.authorTurecki, Gustavoen_US
dc.contributor.authorWray, Naomi R.en_US
dc.contributor.authorWright, Adamen_US
dc.contributor.authorZandi, Peter P.en_US
dc.contributor.authorZilles, Daviden_US
dc.contributor.authorBauer, Michaelen_US
dc.contributor.authorRietschel, Marcellaen_US
dc.contributor.authorMcMahon, Francis J.en_US
dc.contributor.authorSchulze, Thomas G.en_US
dc.contributor.authorAlda, Martinen_US
dc.date.accessioned2014-02-18T18:10:48Z
dc.date.issued2013en_US
dc.identifier.citationManchia, M., M. Adli, N. Akula, R. Ardau, J. Aubry, L. Backlund, C. E. Banzato, et al. 2013. “Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report.” PLoS ONE 8 (6): e65636. doi:10.1371/journal.pone.0065636. http://dx.doi.org/10.1371/journal.pone.0065636.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11717519
dc.description.abstractObjective: The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment of lithium response have been proposed in the literature. In this study we report the key phenotypic measures of the “Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder” scale currently used in the Consortium on Lithium Genetics (ConLiGen) study. Materials and Methods Twenty-nine ConLiGen sites took part in a two-stage case-vignette rating procedure to examine inter-rater agreement [Kappa (κ)] and reliability [intra-class correlation coefficient (ICC)] of lithium response. Annotated first-round vignettes and rating guidelines were circulated to expert research clinicians for training purposes between the two stages. Further, we analyzed the distributional properties of the treatment response scores available for 1,308 patients using mixture modeling. Results: Substantial and moderate agreement was shown across sites in the first and second sets of vignettes (κ = 0.66 and κ = 0.54, respectively), without significant improvement from training. However, definition of response using the A score as a quantitative trait and selecting cases with B criteria of 4 or less showed an improvement between the two stages (ICC1 = 0.71 and ICC2 = 0.75, respectively). Mixture modeling of score distribution indicated three subpopulations (full responders, partial responders, non responders). Conclusions: We identified two definitions of lithium response, one dichotomous and the other continuous, with moderate to substantial inter-rater agreement and reliability. Accurate phenotypic measurement of lithium response is crucial for the ongoing ConLiGen pharmacogenomic study.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0065636en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686769/pdf/en
dash.licenseLAAen_US
dc.subjectBiologyen
dc.subjectComputational Biologyen
dc.subjectGenomicsen
dc.subjectPharmacogenomicsen
dc.subjectGeneticsen
dc.subjectGenome-Wide Association Studiesen
dc.subjectGenomic Medicineen
dc.subjectMedicineen
dc.subjectDrugs and Devicesen
dc.subjectBehavioral Pharmacologyen
dc.subjectNeuropharmacologyen
dc.subjectPharmacogeneticsen
dc.subjectPsychopharmacologyen
dc.subjectEpidemiologyen
dc.subjectPharmacoepidemiologyen
dc.subjectMental Healthen
dc.subjectPsychiatryen
dc.subjectMood Disordersen
dc.subjectPsychologyen
dc.subjectPsychometricsen
dc.subjectTherapiesen
dc.titleAssessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Reporten
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorPerlis, Roy H.en_US
dc.date.available2014-02-18T18:10:48Z
dc.identifier.doi10.1371/journal.pone.0065636*
dash.authorsorderedfalse
dash.contributor.affiliatedSmoller, Jordan
dash.contributor.affiliatedPerlis, Roy


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