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dc.contributor.authorBojarski, Emeric F.en_US
dc.contributor.authorStrauss, Adam C.en_US
dc.contributor.authorFagin, Adam P.en_US
dc.contributor.authorPlantinga, Theo S.en_US
dc.contributor.authorHoischen, Alexanderen_US
dc.contributor.authorVeltman, Jorisen_US
dc.contributor.authorAllsop, Stephen A.en_US
dc.contributor.authorGranadillo, Victor J. Ancianoen_US
dc.contributor.authorWilliam, Arsanien_US
dc.contributor.authorNetea, Mihai G.en_US
dc.contributor.authorDimitrakoff, Jordanen_US
dc.date.accessioned2014-02-18T18:10:53Z
dc.date.issued2013en_US
dc.identifier.citationBojarski, E. F., A. C. Strauss, A. P. Fagin, T. S. Plantinga, A. Hoischen, J. Veltman, S. A. Allsop, et al. 2013. “Novel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Pain.” PLoS ONE 8 (7): e68118. doi:10.1371/journal.pone.0068118. http://dx.doi.org/10.1371/journal.pone.0068118.en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11717531
dc.description.abstractA 44-year-old man is presented here with 14 years of chronic purulent sinusitis, a chronic fungal rash of the scrotum, and chronic pelvic pain. Treatment with antifungal therapy resulted in symptom improvement, however he was unable to establish an effective long-term treatment regimen, resulting in debilitating symptoms. He had undergone extensive work-up without identifying a clear underlying etiology, although Candida species were cultured from the prostatic fluid. 100 genes involved in the cellular immune response were sequenced and a missense mutation was identified in the Ras-binding domain of PI3Kγ. PI3Kγ is a crucial signaling element in leukotaxis and other leukocyte functions. We hypothesize that his mutation led to his chronic infections and pelvic pain.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pone.0068118en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704649/pdf/en
dash.licenseLAAen_US
dc.subjectBiologyen
dc.subjectComputational Biologyen
dc.subjectGenomicsen
dc.subjectGenome Sequencingen
dc.subjectSequence Analysisen
dc.subjectGeneticsen
dc.subjectGenetic Mutationen
dc.subjectMedicineen
dc.subjectClinical Immunologyen
dc.subjectImmune Responseen
dc.subjectInfectious Diseasesen
dc.subjectBacterial Diseasesen
dc.subjectChronic Bacterial Prostatitisen
dc.subjectFungal Diseasesen
dc.subjectSystemic Mycosesen
dc.titleNovel PI3Kγ Mutation in a 44-Year-Old Man with Chronic Infections and Chronic Pelvic Painen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS ONEen
dash.depositing.authorFagin, Adam P.en_US
dc.date.available2014-02-18T18:10:53Z
dc.identifier.doi10.1371/journal.pone.0068118*
dash.authorsorderedfalse
dash.contributor.affiliatedDimitrakoff, Jordan
dash.contributor.affiliatedWilliam, Arsani
dash.contributor.affiliatedFagin, Adam Peter


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