Impact of Adiponectin Overexpression on Allergic Airways Responses in Mice

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Impact of Adiponectin Overexpression on Allergic Airways Responses in Mice

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Title: Impact of Adiponectin Overexpression on Allergic Airways Responses in Mice
Author: Verbout, Norah G.; Benedito, Leandro; Williams, Alison S.; Kasahara, David I.; Wurmbrand, Allison P.; Si, Huiqing; Halayko, Andrew J.; Hug, Christopher; Shore, Stephanie A.

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Citation: Verbout, Norah G., Leandro Benedito, Alison S. Williams, David I. Kasahara, Allison P. Wurmbrand, Huiqing Si, Andrew J. Halayko, Christopher Hug, and Stephanie A. Shore. 2013. “Impact of Adiponectin Overexpression on Allergic Airways Responses in Mice.” Journal of Allergy 2013 (1): 349520. doi:10.1155/2013/349520. http://dx.doi.org/10.1155/2013/349520.
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Abstract: Obesity is an important risk factor for asthma. Obese individuals have decreased circulating adiponectin, an adipose-derived hormone with anti-inflammatory properties. We hypothesized that transgenic overexpression of adiponectin would attenuate allergic airways inflammation and mucous hyperplasia in mice. To test this hypothesis, we used mice overexpressing adiponectin (Adipo Tg). Adipo Tg mice had marked increases in both serum adiponectin and bronchoalveolar lavage (BAL) fluid adiponectin. Both acute and chronic ovalbumin (OVA) sensitization and challenge protocols were used. In both protocols, OVA-induced increases in total BAL cells were attenuated in Adipo Tg versus WT mice. In the acute protocol, OVA-induced increases in several IL-13 dependent genes were attenuated in Adipo Tg versus WT mice, even though IL-13 per se was not affected. With chronic exposure, though OVA-induced increases in goblet cells numbers per millimeter of basement membrane were greater in Adipo Tg versus WT mice, mRNA abundance of mucous genes in lungs was not different. Also, adiponectin overexpression did not induce M2 polarization in alveolar macrophages. Our results indicate that adiponectin protects against allergen-induced inflammatory cell recruitment to the airspaces, but not development of goblet cell hyperplasia.
Published Version: doi:10.1155/2013/349520
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686156/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11717541
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