Show simple item record

dc.contributor.authorVerbout, Norah G.en_US
dc.contributor.authorBenedito, Leandroen_US
dc.contributor.authorWilliams, Alison S.en_US
dc.contributor.authorKasahara, David I.en_US
dc.contributor.authorWurmbrand, Allison P.en_US
dc.contributor.authorSi, Huiqingen_US
dc.contributor.authorHalayko, Andrew J.en_US
dc.contributor.authorHug, Christopheren_US
dc.contributor.authorShore, Stephanie A.en_US
dc.date.accessioned2014-02-18T18:11:02Z
dc.date.issued2013en_US
dc.identifier.citationVerbout, Norah G., Leandro Benedito, Alison S. Williams, David I. Kasahara, Allison P. Wurmbrand, Huiqing Si, Andrew J. Halayko, Christopher Hug, and Stephanie A. Shore. 2013. “Impact of Adiponectin Overexpression on Allergic Airways Responses in Mice.” Journal of Allergy 2013 (1): 349520. doi:10.1155/2013/349520. http://dx.doi.org/10.1155/2013/349520.en
dc.identifier.issn1687-9783en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11717541
dc.description.abstractObesity is an important risk factor for asthma. Obese individuals have decreased circulating adiponectin, an adipose-derived hormone with anti-inflammatory properties. We hypothesized that transgenic overexpression of adiponectin would attenuate allergic airways inflammation and mucous hyperplasia in mice. To test this hypothesis, we used mice overexpressing adiponectin (Adipo Tg). Adipo Tg mice had marked increases in both serum adiponectin and bronchoalveolar lavage (BAL) fluid adiponectin. Both acute and chronic ovalbumin (OVA) sensitization and challenge protocols were used. In both protocols, OVA-induced increases in total BAL cells were attenuated in Adipo Tg versus WT mice. In the acute protocol, OVA-induced increases in several IL-13 dependent genes were attenuated in Adipo Tg versus WT mice, even though IL-13 per se was not affected. With chronic exposure, though OVA-induced increases in goblet cells numbers per millimeter of basement membrane were greater in Adipo Tg versus WT mice, mRNA abundance of mucous genes in lungs was not different. Also, adiponectin overexpression did not induce M2 polarization in alveolar macrophages. Our results indicate that adiponectin protects against allergen-induced inflammatory cell recruitment to the airspaces, but not development of goblet cell hyperplasia.en
dc.language.isoen_USen
dc.publisherHindawi Publishing Corporationen
dc.relation.isversionofdoi:10.1155/2013/349520en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686156/pdf/en
dash.licenseLAAen_US
dc.titleImpact of Adiponectin Overexpression on Allergic Airways Responses in Miceen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalJournal of Allergyen
dash.depositing.authorKasahara, David I.en_US
dc.date.available2014-02-18T18:11:02Z
dc.identifier.doi10.1155/2013/349520*
dash.contributor.affiliatedWurmbrand, Allison Patricia
dash.contributor.affiliatedShore, Stephanie
dash.contributor.affiliatedKasahara, David


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record