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dc.contributor.authorVan Tyne, Dariaen_US
dc.contributor.authorMartin, Melissa J.en_US
dc.contributor.authorGilmore, Michael S.en_US
dc.date.accessioned2014-02-18T18:11:08Z
dc.date.issued2013en_US
dc.identifier.citationVan Tyne, Daria, Melissa J. Martin, and Michael S. Gilmore. 2013. “Structure, Function, and Biology of the Enterococcus faecalis Cytolysin.” Toxins 5 (5): 895-911. doi:10.3390/toxins5050895. http://dx.doi.org/10.3390/toxins5050895.en
dc.identifier.issn2072-6651en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11717548
dc.description.abstractEnterococcus faecalis is a Gram-positive commensal member of the gut microbiota of a wide range of organisms. With the advent of antibiotic therapy, it has emerged as a multidrug resistant, hospital-acquired pathogen. Highly virulent strains of E. faecalis express a pore-forming exotoxin, called cytolysin, which lyses both bacterial and eukaryotic cells in response to quorum signals. Originally described in the 1930s, the cytolysin is a member of a large class of lanthionine-containing bacteriocins produced by Gram-positive bacteria. While the cytolysin shares some core features with other lantibiotics, it possesses unique characteristics as well. The current understanding of cytolysin biosynthesis, structure/function relationships, and contribution to the biology of E. faecalis are reviewed, and opportunities for using emerging technologies to advance this understanding are discussed.en
dc.language.isoen_USen
dc.publisherMDPIen
dc.relation.isversionofdoi:10.3390/toxins5050895en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709268/pdf/en
dash.licenseLAAen_US
dc.subjectcytolysinen
dc.subjectlantibioticen
dc.subjectbacteriocinen
dc.titleStructure, Function, and Biology of the Enterococcus faecalis Cytolysinen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalToxinsen
dash.depositing.authorVan Tyne, Dariaen_US
dc.date.available2014-02-18T18:11:08Z
dc.identifier.doi10.3390/toxins5050895*
dash.contributor.affiliatedVan tyne, Daria
dash.contributor.affiliatedGilmore, Michael
dash.contributor.affiliatedMartin, Melissa Janet


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