Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins
McLaughlin-Drubin, Margaret E.
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CitationMcLaughlin-Drubin, Margaret E., and Karl Munger. 2013. “Biochemical and Functional Interactions of Human Papillomavirus Proteins with Polycomb Group Proteins.” Viruses 5 (5): 1231-1249. doi:10.3390/v5051231. http://dx.doi.org/10.3390/v5051231.
AbstractThe role of enzymes involved in polycomb repression of gene transcription has been studied extensively in human cancer. Polycomb repressive complexes mediate oncogene-induced senescence, a principal innate cell-intrinsic tumor suppressor pathway that thwarts expansion of cells that have suffered oncogenic hits. Infections with human cancer viruses including human papillomaviruses (HPVs) and Epstein-Barr virus can trigger oncogene-induced senescence, and the viruses have evolved strategies to abrogate this response in order to establish an infection and reprogram their host cells to establish a long-term persistent infection. As a consequence of inhibiting polycomb repression and evading oncogene induced-senescence, HPV infected cells have an altered epigenetic program as evidenced by aberrant homeobox gene expression. Similar alterations are frequently observed in non-virus associated human cancers and may be harnessed for diagnosis and therapy.
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