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dc.contributor.authorLu, Bingen_US
dc.contributor.authorAhmad, Oneeben_US
dc.contributor.authorZhang, Fang-Fangen_US
dc.contributor.authorDriban, Jeffrey Ben_US
dc.contributor.authorDuryea, Jeffreyen_US
dc.contributor.authorLapane, Kate Len_US
dc.contributor.authorMcAlindon, Timothyen_US
dc.contributor.authorEaton, Charles Ben_US
dc.date.accessioned2014-02-18T18:11:42Z
dc.date.issued2013en_US
dc.identifier.citationLu, Bing, Oneeb Ahmad, Fang-Fang Zhang, Jeffrey B Driban, Jeffrey Duryea, Kate L Lapane, Timothy McAlindon, and Charles B Eaton. 2013. “Soft drink intake and progression of radiographic knee osteoarthritis: data from the osteoarthritis initiative.” BMJ Open 3 (7): e002993. doi:10.1136/bmjopen-2013-002993. http://dx.doi.org/10.1136/bmjopen-2013-002993.en
dc.identifier.issn2044-6055en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11717608
dc.description.abstractObjectives: We examine the prospective association of soft drink consumption with radiographic progression of knee osteoarthritis (OA). Design: Prospective cohort study. Setting: This study used data from the osteoarthritis initiative (OAI). Participants: In OAI, 2149 participants with radiographic knee OA and having dietary data at baseline were followed up to 12, 24, 36 and 48 months. Measures The soft drink consumption was assessed with a Block Brief Food Frequency Questionnaire completed at baseline. To evaluate knee OA progression, we used quantitative medial tibiofemoral joint space width (JSW) based on plain radiographs. The multivariate linear models for repeated measures were used to test the independent association between soft drink intake and the change in JSW over time, while adjusting for body mass index and other potential confounding factors. Results: In stratified analyses by gender, we observed a significant dose–response relationship between baseline soft drink intake and adjusted mean change of JSW in men. With increasing levels of soft drink intake (none, ≤1, 2–4 and ≥5 times/week), the mean decreases of JSW were 0.31, 0.39, 0.34 and 0.60 mm, respectively. When we further stratified by obesity, a stronger dose–response relationship was found in non-obese men. In obese men, only the highest soft drink level (≥5 times/week) was associated with increased change in JSW compared with no use. In women, no significant association was observed. Conclusions: Our results suggest that frequent consumption of soft drinks may be associated with increased OA progression in men. Replication of these novel findings in other studies demonstrating the reduction in soft drink consumption leads to delay in OA progression is needed.en
dc.language.isoen_USen
dc.publisherBMJ Publishing Groupen
dc.relation.isversionofdoi:10.1136/bmjopen-2013-002993en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717463/pdf/en
dash.licenseLAAen_US
dc.subjectRheumatologyen
dc.subjectNutrition & Dieteticsen
dc.titleSoft drink intake and progression of radiographic knee osteoarthritis: data from the osteoarthritis initiativeen
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalBMJ Openen
dash.depositing.authorLu, Bingen_US
dc.date.available2014-02-18T18:11:42Z
dc.identifier.doi10.1136/bmjopen-2013-002993*
dash.contributor.affiliatedDuryea, Jeffrey
dash.contributor.affiliatedLu, Bing


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