Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2

DSpace/Manakin Repository

Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2

Citable link to this page

 

 
Title: Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2
Author: Wang, Zhiwei; Inuzuka, Hiroyuki; Zhong, Jiateng; Liu, Pengda; Sarkar, Fazlul H.; Sun, Yi; Wei, Wenyi

Note: Order does not necessarily reflect citation order of authors.

Citation: Wang, Zhiwei, Hiroyuki Inuzuka, Jiateng Zhong, Pengda Liu, Fazlul H. Sarkar, Yi Sun, and Wenyi Wei. 2012. “Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2.” Oncotarget 3 (11): 1294-1300.
Full Text & Related Files:
Abstract: The Skp2 (S-phase kinase associated protein 2) oncoprotein is often highly expressed in various types of human cancers. However, the mechanistic basis of its oncogenic function, as well as the upstream regulatory pathway(s) that control Skp2 activities remains not fully understood. Recently, we reported that p300 acetylates Skp2 at two conserved lysine residues K68 and K71 within its NLS (Nuclear localization signal). This modification leads to increased Skp2 stability and cytoplasmic translocation, thus contributing to elevated Skp2 oncogenic potential. Moreover, we found that the SIRT3 tumor suppressor serves as the physiological deacetylase that antagonizes p300-mediated Skp2 acetylation. Furthermore, we showed that Skp2 governs E-cadherin ubiquitination and degradation in the cytosol. Consistent with this, we observed an inverse correlation between Skp2 and E-cadherin expression in clinical breast tumor samples. Therefore, our work elucidates a novel acetylation-dependent regulatory mechanism for Skp2 oncogenic functions.
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717793/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11717610
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters