dc.contributor.author | BIRRANE, GABRIEL | en_US |
dc.contributor.author | LI, HUCHUN | en_US |
dc.contributor.author | YANG, SUPING | en_US |
dc.contributor.author | TACHADO, SOUVENIR D. | en_US |
dc.contributor.author | SENG, SEYHA | en_US |
dc.date.accessioned | 2014-02-18T18:12:00Z | |
dc.date.issued | 2013 | en_US |
dc.identifier.citation | BIRRANE, GABRIEL, HUCHUN LI, SUPING YANG, SOUVENIR D. TACHADO, and SEYHA SENG. 2013. “Cigarette smoke induces nuclear translocation of heme oxygenase 1 (HO-1) in prostate cancer cells: Nuclear HO-1 promotes vascular endothelial growth factor secretion.” International Journal of Oncology 42 (6): 1919-1928. doi:10.3892/ijo.2013.1910. http://dx.doi.org/10.3892/ijo.2013.1910. | en |
dc.identifier.issn | 1019-6439 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11717665 | |
dc.description.abstract | Prostate cancer is the second leading cause of male-cancer related death in the United States. Despite a number of evidence-based studies which strongly suggest an association between cigarette smoking and prostate cancer, the underlying biological mechanism is largely unknown. Heme oxygenase 1 (HO-1) has been implicated in maintaining cellular homeostasis, but also in tumor angiogenesis. Nuclear HO-1 protein expression has been observed in various types of tumors including prostate cancer. These studies, however, were reported as clinical and pathological observations, and failed to investigate nuclear HO-1 at the molecular level in cancer. The present study explores the relationship between cigarette smoke and nuclear HO-1-modulated promotion of vascular endothelial growth factor (VEGF) secretion. We have demonstrated that cigarette smoke medium (SM)-induced HO-1 mRNA expression and upregulated HO-1 protein levels in the prostate cancer cell lines DU145 and PC3. We also observed that SM significantly induced nuclear expression of HO-1, and enhanced secretion of VEGF in cells. Nuclear-directed expression of HO-1 activated the transcriptional activity of VEGF and promoted VEGF secretion in prostate cancer cells. This study provides new insights into the molecular mechanism by which cigarette smoke-induced nuclear translocation of HO-1 promotes VEGF secretion in prostate cancer cells. Nuclear HO-1 may, therefore, constitute an attractive therapeutic target to inhibit angiogenesis and the progression of prostate cancer. | en |
dc.language.iso | en_US | en |
dc.publisher | D.A. Spandidos | en |
dc.relation.isversionof | doi:10.3892/ijo.2013.1910 | en |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3699615/pdf/ | en |
dash.license | LAA | en_US |
dc.subject | cigarette smoke | en |
dc.subject | nuclear heme oxygenase 1 | en |
dc.subject | vascular endothelial growth factor | en |
dc.subject | prostate cancer | en |
dc.title | Cigarette smoke induces nuclear translocation of heme oxygenase 1 (HO-1) in prostate cancer cells: Nuclear HO-1 promotes vascular endothelial growth factor secretion | en |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en |
dc.relation.journal | International Journal of Oncology | en |
dash.depositing.author | BIRRANE, GABRIEL | en_US |
dc.date.available | 2014-02-18T18:12:00Z | |
dc.identifier.doi | 10.3892/ijo.2013.1910 | * |
dash.contributor.affiliated | Yang, Suping | |
dash.contributor.affiliated | Seng, Seyha | |
dash.contributor.affiliated | Tachado, Souvenir | |
dash.contributor.affiliated | Birrane, Gabriel | |