Mouse Ooplasm Confers Context-Specific Reprogramming Capacity
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CitationChan, Michelle M., Zachary D. Smith, Dieter Egli, Aviv Regev, and Alexander Meissner. 2012. Mouse ooplasm confers context-specific reprogramming capacity. Nature Genetics 44(9): 978-980.
AbstractEnucleated oocytes have the remarkable ability to reprogram somatic nuclei back to totipotency. Here we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer such as germ-line associated promoters, as well as unique limitations that include certain repetitive element classes.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11722992
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