Mouse Ooplasm Confers Context-Specific Reprogramming Capacity

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Mouse Ooplasm Confers Context-Specific Reprogramming Capacity

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Title: Mouse Ooplasm Confers Context-Specific Reprogramming Capacity
Author: Chan, Michelle; Smith, Zachary D; Egli, Dieter; Regev, Aviv; Meissner, Alexander

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Citation: Chan, Michelle M., Zachary D. Smith, Dieter Egli, Aviv Regev, and Alexander Meissner. 2012. Mouse ooplasm confers context-specific reprogramming capacity. Nature Genetics 44(9): 978-980.
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Abstract: Enucleated oocytes have the remarkable ability to reprogram somatic nuclei back to totipotency. Here we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer such as germ-line associated promoters, as well as unique limitations that include certain repetitive element classes.
Published Version: doi:10.1038/ng.2382
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