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dc.contributor.authorAlim, Karen
dc.contributor.authorHamant, Olivier
dc.contributor.authorBoudaoud, Arezki
dc.date.accessioned2014-02-20T21:19:18Z
dc.date.issued2012
dc.identifier.citationAlim, Karen, Olivier Hamant, and Arezki Boudaoud. 2012. Regulatory role of cell division rules on tissue growth heterogeneity. Frontiers in Plant Science 3: 174.en_US
dc.identifier.issn1664-462Xen_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11726259
dc.description.abstractThe coordination of cell division and cell expansion are critical to normal development of tissues. In plants, cell wall mechanics and the there from arising cell shapes and mechanical stresses can regulate cell division and cell expansion and thereby tissue growth and morphology. Limited by experimental accessibility it remains unknown how cell division and expansion cooperatively affect tissue growth dynamics. Employing a cell-based two dimensional tissue simulation we investigate the regulatory role of a range of cell division rules on tissue growth dynamics and in particular on the spatial heterogeneity of growth. We find that random cell divisions only add noise to the growth and therefore increase growth heterogeneity, while cell divisions following the shortest new wall or along the direction of maximal mechanical stress reduce growth heterogeneity by actively enhancing the regulation of growth by mechanical stresses. Thus, we find that, beyond tissue geometry and topology, cell divisions affect the dynamics of growth, and that their signature is embedded in the statistics of tissue growth.en_US
dc.description.sponsorshipEngineering and Applied Sciencesen_US
dc.language.isoen_USen_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.isversionofdoi:10.3389/fpls.2012.00174en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414725/pdf/en_US
dash.licenseLAA
dc.titleRegulatory Role of Cell Division Rules on Tissue Growth Heterogeneityen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalFrontiers in Plant Scienceen_US
dash.depositing.authorAlim, Karen
dc.date.available2014-02-20T21:19:18Z
dc.identifier.doi10.3389/fpls.2012.00174*
dash.contributor.affiliatedAlim, Karen


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