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dc.contributor.authorHooley, Jill Miranda
dc.contributor.authorSiegle, Greg
dc.contributor.authorGruber, Staci Ann
dc.date.accessioned2014-02-20T21:29:45Z
dc.date.issued2012
dc.identifier.citationHooley, Jill M., Greg Siegle, and Staci A. Gruber. 2012. Affective and neural reactivity to criticism in individuals high and low on perceived criticism. PLoS ONE 7(9): e44412.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11726262
dc.description.abstractPeople who have remitted from depression are at increased risk for relapse if they rate their relatives as being critical of them on a simple self-report measure of Perceived Criticism (PC). To explore neural mechanisms associated with this we used functional magnetic resonance imaging (fMRI) to examine how people with different levels of PC responded to hearing criticism from their own mothers. To maximize variability in affective reactivity, depressed, recovered depressed, and healthy control participants (n = 33) were classified as high or low in PC based on a median split. They were then exposed to personally-relevant critical and praising comments from their mothers. Perceived Criticism levels were unrelated to depression status and to negative mood change after hearing criticism. However, compared to low PC participants, those who scored high on PC showed differential activation in a network of regions associated with emotion reactivity and regulation, including increased amygdala activity and decreased reactions in prefrontal regulatory regions when they heard criticism. This was not the case for praise. Criticism may be a risk factor for relapse because it helps to “train” pathways characteristic of depressive information processing. The Perceived Criticism measure may help identify people who are more susceptible to this vulnerability.en_US
dc.description.sponsorshipPsychologyen_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0044412en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439418/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectNeuroscienceen_US
dc.subjectNeuroimagingen_US
dc.subjectFmrien_US
dc.subjectMedicineen_US
dc.subjectMental Healthen_US
dc.subjectPsychiatryen_US
dc.subjectMood Disordersen_US
dc.subjectPsychosesen_US
dc.subjectSubstance Abuseen_US
dc.subjectPsychologyen_US
dc.subjectBehavioren_US
dc.subjectEmotionsen_US
dc.subjectClinical Psychologyen_US
dc.subjectHuman Relationsen_US
dc.subjectPsychological Stressen_US
dc.titleAffective and Neural Reactivity to Criticism in Individuals High and Low on Perceived Criticismen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorHooley, Jill Miranda
dc.date.available2014-02-20T21:29:45Z
dc.identifier.doi10.1371/journal.pone.0044412*
dash.contributor.affiliatedGruber, Staci
dash.contributor.affiliatedHooley, Jill


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