Adaptation at the output of the chemotaxis signalling pathway
Citation
Yuan, Junhua, Richard W. Branch, Basarab G. Hosu, and Howard C. Berg. 2012. Adaptation at the output of the chemotaxis signalling pathway. Nature 484(7393): 233-236.Abstract
In the bacterial chemotaxis network, receptor clusters process input1–3, and flagellar motors generate output4. Receptor and motor complexes are coupled by the diffusible protein CheY-P. Receptor output (the steady-state concentration of CheY-P) varies from cell to cell5. However, the motor is ultrasensitive, with a narrow [CheY-P] operating range6. How might the match between receptor output and motor input be optimized? Here we show that the motor can shift its operating range by changing its composition. The number of FliM subunits in the C-ring increases in response to a decrement in the concentration of CheY-P, increasing motor sensitivity. This shift in sensitivity explains the slow partial adaptation observed in mutants that lack the receptor methyltransferase and methylesterase7–8 and why motors exhibit signal-dependent FliM turnover9. Adaptive remodelling is likely to be a common feature in the operation of many molecular machines.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335734/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11726264
Collections
- FAS Scholarly Articles [17190]
Contact administrator regarding this item (to report mistakes or request changes)
Comments made during the workflow steps
FLAG-WEIRD I wonder how we got this on a pub med ingest? In any case, uner nature's policy can post after 6 months per sherpa romeo