Adaptation at the output of the chemotaxis signalling pathway

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Adaptation at the output of the chemotaxis signalling pathway

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Title: Adaptation at the output of the chemotaxis signalling pathway
Author: Yuan, Junhua; Branch, Richard William; Hosu, Basarab Gabriel; Berg, Howard Curtis

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Citation: Yuan, Junhua, Richard W. Branch, Basarab G. Hosu, and Howard C. Berg. 2012. Adaptation at the output of the chemotaxis signalling pathway. Nature 484(7393): 233-236.
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Abstract: In the bacterial chemotaxis network, receptor clusters process input1–3, and flagellar motors generate output4. Receptor and motor complexes are coupled by the diffusible protein CheY-P. Receptor output (the steady-state concentration of CheY-P) varies from cell to cell5. However, the motor is ultrasensitive, with a narrow [CheY-P] operating range6. How might the match between receptor output and motor input be optimized? Here we show that the motor can shift its operating range by changing its composition. The number of FliM subunits in the C-ring increases in response to a decrement in the concentration of CheY-P, increasing motor sensitivity. This shift in sensitivity explains the slow partial adaptation observed in mutants that lack the receptor methyltransferase and methylesterase7–8 and why motors exhibit signal-dependent FliM turnover9. Adaptive remodelling is likely to be a common feature in the operation of many molecular machines.
Published Version: doi:10.1038/nature10964
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3335734/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11726264
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