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dc.contributor.authorSalter, S. J.
dc.contributor.authorHinds, J.
dc.contributor.authorGould, K. A.
dc.contributor.authorLambertsen, L.
dc.contributor.authorHanage, William P.
dc.contributor.authorAntonio, M.
dc.contributor.authorTurner, P.
dc.contributor.authorHermans, P. W. M.
dc.contributor.authorBootsma, H. J.
dc.contributor.authorO'Brien, K. L.
dc.contributor.authorBentley, S. D.
dc.date.accessioned2014-02-21T14:19:38Z
dc.date.issued2012
dc.identifier.citationSalter, S. J., J. Hinds, K. A. Gould, L. Lambertsen, William P. Hanage, M. Antonio, P. Turner, et al. 2012. Variation at the capsule locus, cps, of mistyped and non-typable streptococcus pneumoniae isolates. Microbiology 158(Pt 6): 1560-1569.en_US
dc.identifier.issn1350-0872en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11726274
dc.description.abstractThe capsule polysaccharide locus (cps) is the site of the capsule biosynthesis gene cluster in encapsulated Streptococcus pneumoniae. A set of pneumococcal samples and non-pneumococcal streptococci from Denmark, the Gambia, the Netherlands, Thailand, the UK and the USA were sequenced at the cps locus to elucidate serologically mistyped or non-typable isolates. We identified a novel serotype 33B/33C mosaic capsule cluster and previously unseen serotype 22F capsule genes, disrupted and deleted cps clusters, the presence of aliB and nspA genes that are unrelated to capsule production, and similar genes in the non-pneumococcal samples. These data provide greater understanding of diversity at a locus which is crucial to the antigenic diversity of the pathogen and current vaccine strategies.en_US
dc.language.isoen_USen_US
dc.publisherSociety for General Microbiologyen_US
dc.relation.isversionofdoi:10.1099/mic.0.056580-0en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541774/pdf/en_US
dash.licenseLAA
dc.subjectStandarden_US
dc.titleVariation at the capsule locus, cps, of mistyped and non-typable Streptococcus pneumoniae isolatesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalMicrobiologyen_US
dash.depositing.authorHanage, William P.
dc.date.available2014-02-21T14:19:38Z
dc.identifier.doi10.1099/mic.0.056580-0*
dash.authorsorderedfalse
dash.contributor.affiliatedHanage, William


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