Crystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease H
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Crystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease H
| Title: | Crystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease H |
| Author: |
Kim, Ju Hee; Kang, Sunghyun; Jung, Suk-Kyeong; Yu, Keum Ran; Chung, Sang J.; Chung, Bong Hyun; Erikson, Raymond Leo; Kim, Bo Yeon; Kim, Seung Jun
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Kim, Ju Hee, Sunghyun Kang, Suk-Kyeong Jung, Keum Ran Yu, Sang J. Chung, Bong Hyun Chung, Raymond L. Erikson, Bo Yeon Kim, and Seung Jun Kim. 2012. Crystal structure of xenotropic murine leukaemia virus-related virus (xmrv) ribonuclease h. Bioscience Reports 32(Pt 5): 455-463. |
| Full Text & Related Files: |
3475449.pdf (942.5Kb; PDF) 
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| Abstract: | RNase H (retroviral ribonuclease H) cleaves the phosphate backbone of the RNA template within an RNA/DNA hybrid to complete the synthesis of double-stranded viral DNA. In the present study we have determined the complete structure of the RNase H domain from XMRV (xenotropic murine leukaemia virus-related virus) RT (reverse transcriptase). The basic protrusion motif of the XMRV RNase H domain is folded as a short helix and an adjacent highly bent loop. Structural superposition and subsequent mutagenesis experiments suggest that the basic protrusion motif plays a role in direct binding to the major groove in RNA/DNA hybrid, as well as in establishing the co-ordination among modules in RT necessary for proper function. |
| Published Version: | doi:10.1042/BSR20120028 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475449/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11729584 |
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