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dc.contributor.authorXi, Zhenxiang
dc.contributor.authorBradley, Robert K
dc.contributor.authorWurdack, Kenneth J
dc.contributor.authorWong, KM
dc.contributor.authorSugumaran, M
dc.contributor.authorBomblies, Kirsten
dc.contributor.authorRest, Joshua S
dc.contributor.authorDavis, Charles Cavender
dc.date.accessioned2014-02-21T19:38:12Z
dc.date.issued2012
dc.identifier.citationXi, Zhenxiang, Robert K Bradley, Kenneth J Wurdack, KM Wong, M Sugumaran, Kirsten Bomblies, Joshua S Rest, and Charles C Davis. 2012. Horizontal transfer of expressed genes in a parasitic flowering plant. BMC Genomics 13: 227.en_US
dc.identifier.issn1471-2164en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11729586
dc.description.abstractBackground: Recent studies have shown that plant genomes have potentially undergone rampant horizontal gene transfer (HGT). In plant parasitic systems HGT appears to be facilitated by the intimate physical association between the parasite and its host. HGT in these systems has been invoked when a DNA sequence obtained from a parasite is placed phylogenetically very near to its host rather than with its closest relatives. Studies of HGT in parasitic plants have relied largely on the fortuitous discovery of gene phylogenies that indicate HGT, and no broad systematic search for HGT has been undertaken in parasitic systems where it is most expected to occur. Results: We analyzed the transcriptomes of the holoparasite Rafflesia cantleyi Solms-Laubach and its obligate host Tetrastigma rafflesiae Miq. using phylogenomic approaches. Our analyses show that several dozen actively transcribed genes, most of which appear to be encoded in the nuclear genome, are likely of host origin. We also find that hundreds of vertically inherited genes (VGT) in this parasitic plant exhibit codon usage properties that are more similar to its host than to its closest relatives. Conclusions: Our results establish for the first time a substantive number of HGTs in a plant host-parasite system. The elevated rate of unidirectional host-to- parasite gene transfer raises the possibility that HGTs may provide a fitness benefit to Rafflesia for maintaining these genes. Finally, a similar convergence in codon usage of VGTs has been shown in microbes with high HGT rates, which may help to explain the increase of HGTs in these parasitic plants.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1471-2164-13-227en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460754/pdf/en_US
dash.licenseLAA
dc.subjectTranscriptomeen_US
dc.subjectPhylogenomicsen_US
dc.subjectHorizontal gene transferen_US
dc.subjectCodon usageen_US
dc.titleHorizontal transfer of expressed genes in a parasitic flowering planten_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMC Genomicsen_US
dash.depositing.authorBomblies, Kirsten
dc.date.available2014-02-21T19:38:12Z
dc.identifier.doi10.1186/1471-2164-13-227*
dash.contributor.affiliatedXi, Zhenxiang
dash.contributor.affiliatedBomblies, Kirsten
dash.contributor.affiliatedDavis, Charles


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