Direction selectivity in the larval zebrafish tectum is mediated by asymmetric inhibition

DSpace/Manakin Repository

Direction selectivity in the larval zebrafish tectum is mediated by asymmetric inhibition

Citable link to this page

 

 
Title: Direction selectivity in the larval zebrafish tectum is mediated by asymmetric inhibition
Author: Grama, Abhinav Satish; Engert, Florian

Note: Order does not necessarily reflect citation order of authors.

Citation: Grama, Abhinav, and Florian Engert. 2012. Direction selectivity in the larval zebrafish tectum is mediated by asymmetric inhibition. Frontiers in Neural Circuits 6: 59.
Full Text & Related Files:
Abstract: The extraction of the direction of motion is an important computation performed by many sensory systems and in particular, the mechanism by which direction-selective retinal ganglion cells (DS-RGCs) in the retina acquire their selective properties, has been studied extensively. However, whether DS-RGCs simply relay this information to downstream areas or whether additional and potentially de novo processing occurs in these recipient structures is a matter of great interest. Neurons in the larval zebrafish tectum, the largest retino-recipent area in this animal, show direction-selective (DS) responses to moving visual stimuli but how these properties are acquired is still unknown. In order to study this, we first used two-photon calcium imaging to classify the population responses of tectal cells to bars moving at different speeds and in different directions. Subsequently, we performed in vivo whole cell electrophysiology on these DS tectal neurons and we found that their inhibitory inputs were strongly biased toward the null direction of motion, whereas the excitatory inputs showed little selectivity. In addition, we found that excitatory currents evoked by a stimulus moving in the preferred direction occurred before the inhibitory currents whereas a stimulus moving in the null direction evoked currents in the reverse temporal order. The membrane potential modulations resulting from these currents were enhanced by the spike generation mechanism to generate amplified direction selectivity in the spike output. Thus, our results implicate a local inhibitory circuit in generating direction selectivity in tectal neurons.
Published Version: doi:10.3389/fncir.2012.00059
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432856/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11732119
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters