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dc.contributor.authorWright, Kevin M.
dc.contributor.authorLloyd, Deborah
dc.contributor.authorLowry, David B.
dc.contributor.authorMacnair, Mark R.
dc.contributor.authorWillis, John H.
dc.date.accessioned2014-02-21T21:32:55Z
dc.date.issued2013
dc.identifier.citationWright, Kevin M., Deborah Lloyd, David B. Lowry, Mark R. Macnair, and John H. Willis. 2013. Indirect evolution of hybrid lethality due to linkage with selected locus in Mimulus guttatus. PLoS Biology 11(2): e1001497.en_US
dc.identifier.issn1544-9173en_US
dc.identifier.issn1545-7885en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11732167
dc.description.abstractMost species are superbly and intricately adapted to the environments in which they live. Adaptive evolution by natural selection is the primary force shaping biological diversity. Differences between closely related species in ecologically selected characters such as habitat preference, reproductive timing, courtship behavior, or pollinator attraction may prevent interbreeding in nature, causing reproductive isolation. But does ecological adaptation cause reproductive incompatibilities such as hybrid sterility or lethality? Although several genes causing hybrid incompatibilities have been identified, there is intense debate over whether the genes that contribute to ecological adaptations also cause hybrid incompatibilities. Thirty years ago, a genetic study of local adaptation to copper mine soils in the wildflower Mimulus guttatus identified a locus that appeared to cause copper tolerance and hybrid lethality in crosses to other populations. But do copper tolerance and hybrid lethality have the same molecular genetic basis? Here we show, using high-resolution genome mapping, that copper tolerance and hybrid lethality are not caused by the same gene but are in fact separately controlled by two tightly linked loci. We further show that selection on the copper tolerance locus indirectly caused the hybrid incompatibility allele to go to high frequency in the copper mine population because of hitchhiking. Our results provide a new twist on Darwin's original supposition that hybrid incompatibilities evolve as an incidental by-product of ordinary adaptation to the environment.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pbio.1001497en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582499/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectEvolutionary Biologyen_US
dc.subjectEvolutionary Ecologyen_US
dc.subjectEvolutionary Geneticsen_US
dc.subjectEvolutionary Processesen_US
dc.subjectPopulation Geneticsen_US
dc.subjectGeneticsen_US
dc.subjectHeredityen_US
dc.subjectComplex Traitsen_US
dc.subjectGene Flowen_US
dc.subjectGenotypesen_US
dc.subjectLinkage (Genetics)en_US
dc.subjectPhenotypesen_US
dc.subjectQuantitative Traitsen_US
dc.subjectTrait Locusen_US
dc.subjectPlant Scienceen_US
dc.subjectPlant Evolutionen_US
dc.subjectPlant Geneticsen_US
dc.titleIndirect Evolution of Hybrid Lethality due to Linkage with Selected Locus in Mimulus guttatusen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS Biologyen_US
dash.depositing.authorWright, Kevin M.
dc.date.available2014-02-21T21:32:55Z
dc.identifier.doi10.1371/journal.pbio.1001497*
dash.contributor.affiliatedWright, K


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