dc.contributor.advisor | Yin, Peng | |
dc.contributor.author | Sadowski, John Paul | |
dc.date.accessioned | 2014-02-25T19:01:01Z | |
dash.embargo.terms | 2015-02-04 | en_US |
dash.embargo.terms | 2015-02-04 | |
dc.date.issued | 2014-02-25 | |
dc.date.submitted | 2013 | |
dc.identifier.citation | Sadowski, John Paul. 2014. Design and synthesis of dynamically assembling DNA nanostructures. Doctoral dissertation, Harvard University. | en_US |
dc.identifier.other | http://dissertations.umi.com/gsas.harvard:11272 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11744466 | |
dc.description.abstract | Kinetically controlled isothermal growth is fundamental to biological development, but it remains challenging to rationally design molecular systems that self-assemble isothermally into complex geometries via prescribed assembly and disassembly pathways. By exploiting the programmable chemistry of base pairing, sophisticated spatial and temporal control have both been demonstrated in DNA self-assembly, but largely as separate pursuits. This dissertation extends a new approach, called developmental self-assembly, that integrates temporal with spatial control by using a prescriptive molecular program to specify the kinetic pathways by which DNA molecules isothermally self-assemble into well-defined three-dimensional geometries. | en_US |
dc.description.sponsorship | Chemistry and Chemical Biology | en_US |
dc.language.iso | en_US | en_US |
dash.license | LAA | |
dc.subject | Chemistry | en_US |
dc.subject | Nanotechnology | en_US |
dc.subject | Biophysics | en_US |
dc.subject | Bioengineering | en_US |
dc.subject | DNA nanotechnology | en_US |
dc.subject | Molecular self-assembly | en_US |
dc.subject | Nanotechnology | en_US |
dc.subject | Nucleic acid design | en_US |
dc.subject | Synthetic biology | en_US |
dc.title | Design and synthesis of dynamically assembling DNA nanostructures | en_US |
dc.type | Thesis or Dissertation | en_US |
dash.depositing.author | Sadowski, John Paul | |
dc.date.available | 2015-02-04T08:30:41Z | |
thesis.degree.date | 2014 | en_US |
thesis.degree.discipline | Chemistry and Chemical Biology | en_US |
thesis.degree.grantor | Harvard University | en_US |
thesis.degree.level | doctoral | en_US |
thesis.degree.name | Ph.D. | en_US |
dc.contributor.committeeMember | Liu, David | en_US |
dc.contributor.committeeMember | Cohen, Adam | en_US |
dash.contributor.affiliated | Sadowski, John | |