Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation
Carlin, Stephen M.
Moseley, Christian K.
MetadataShow full item record
CitationKamlet, Adam S., Constanze N. Neumann, Eunsung Lee, Stephen M. Carlin, Christian K. Moseley, Nickeisha Stephenson, Jacob M. Hooker, and Tobias Ritter. 2013. Application of palladium-mediated 18f-fluorination to pet radiotracer development: overcoming hurdles to translation. PLoS ONE 8(3): e59187.
AbstractNew chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated. However, progression of modern reactions from the stage of synthetic chemistry development to the preparation of radiotracer doses ready for use in human PET imaging is challenging and rare. Here we describe the process of and the successful translation of a modern palladium-mediated fluorination reaction to non-human primate (NHP) baboon PET imaging–an important milestone on the path to human PET imaging. The method, which transforms [18F]fluoride into an electrophilic fluorination reagent, provides access to aryl–18F bonds that would be challenging to synthesize via conventional radiochemistry methods.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11800764
Showing items related by title, author, creator and subject.
High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry Hillion, Francois; McMahon, Greg; Benson, Douglas; Distel, Daniel; Luyten, Yvette; Schwartz, Martin; Slodzian, Georges; Lechene, Claude P.; Bonventre, Joseph Vincent; Hentschel, Dirk Manfred; Park, Kwon Moo; Ito, Susumu; Benichou, Gilles A.; Kleinfeld, Alan M.; Kampf, J. Patrick (BioMed Central, 2006)Background: Secondary-ion mass spectrometry (SIMS) is an important tool for investigating isotopic composition in the chemical and materials sciences, but its use in biology has been limited by technical considerations. ...
Florine, Emily M.; Miller, Rachel E.; Liebesny, Paul H.; Mroszczyk, Keri A.; Lee, Richard Theodore; Patwari, Parth; Grodzinsky, Alan J. (Mary Ann Liebert Inc, 2015)Heparin-binding insulin-like growth factor 1 (HB-IGF-1) is a fusion protein of IGF-1 with the HB domain of heparin-binding epidermal growth factor-like growth factor. A single dose of HB-IGF-1 has been shown to bind ...
Cloud-Enabled Microscopy and Droplet Microfluidic Platform for Specific Detection of Escherichia coli in Water Golberg, Alexander; Linshiz, Gregory; Kravets, Ilia; Stawski, Nina; Hillson, Nathan J.; Yarmush, Martin L.; Marks, Robert S.; Konry, Tania (Public Library of Science, 2014)We report an all-in-one platform – ScanDrop – for the rapid and specific capture, detection, and identification of bacteria in drinking water. The ScanDrop platform integrates droplet microfluidics, a portable imaging ...