Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation

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Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation

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Title: Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation
Author: Kamlet, Adam; Neumann, Constanze Nicole; Lee, Eunsung; Carlin, Stephen M.; Moseley, Christian K.; Stephenson, Nickeisha A; Hooker, Jacob M; Ritter, Tobias

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Citation: Kamlet, Adam S., Constanze N. Neumann, Eunsung Lee, Stephen M. Carlin, Christian K. Moseley, Nickeisha Stephenson, Jacob M. Hooker, and Tobias Ritter. 2013. Application of palladium-mediated 18f-fluorination to pet radiotracer development: overcoming hurdles to translation. PLoS ONE 8(3): e59187.
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Abstract: New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated. However, progression of modern reactions from the stage of synthetic chemistry development to the preparation of radiotracer doses ready for use in human PET imaging is challenging and rare. Here we describe the process of and the successful translation of a modern palladium-mediated fluorination reaction to non-human primate (NHP) baboon PET imaging–an important milestone on the path to human PET imaging. The method, which transforms [18F]fluoride into an electrophilic fluorination reagent, provides access to aryl–18F bonds that would be challenging to synthesize via conventional radiochemistry methods.
Published Version: doi:10.1371/journal.pone.0059187
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595243/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11800764
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