dc.contributor.author | Kamlet, Adam | |
dc.contributor.author | Neumann, Constanze Nicole | |
dc.contributor.author | Lee, Eunsung | |
dc.contributor.author | Carlin, Stephen M. | |
dc.contributor.author | Moseley, Christian K. | |
dc.contributor.author | Stephenson, Nickeisha A | |
dc.contributor.author | Hooker, Jacob M | |
dc.contributor.author | Ritter, Tobias | |
dc.date.accessioned | 2014-02-26T12:46:25Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Kamlet, Adam S., Constanze N. Neumann, Eunsung Lee, Stephen M. Carlin, Christian K. Moseley, Nickeisha Stephenson, Jacob M. Hooker, and Tobias Ritter. 2013. Application of palladium-mediated 18f-fluorination to pet radiotracer development: overcoming hurdles to translation. PLoS ONE 8(3): e59187. | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11800764 | |
dc.description.abstract | New chemistry methods for the synthesis of radiolabeled small molecules have the potential to impact clinical positron emission tomography (PET) imaging, if they can be successfully translated. However, progression of modern reactions from the stage of synthetic chemistry development to the preparation of radiotracer doses ready for use in human PET imaging is challenging and rare. Here we describe the process of and the successful translation of a modern palladium-mediated fluorination reaction to non-human primate (NHP) baboon PET imaging–an important milestone on the path to human PET imaging. The method, which transforms [18F]fluoride into an electrophilic fluorination reagent, provides access to aryl–18F bonds that would be challenging to synthesize via conventional radiochemistry methods. | en_US |
dc.description.sponsorship | Chemistry and Chemical Biology | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.isversionof | doi:10.1371/journal.pone.0059187 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595243/pdf/ | en_US |
dash.license | LAA | |
dc.subject | Biology | en_US |
dc.subject | Biochemistry | en_US |
dc.subject | Small Molecules | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Organic Chemistry | en_US |
dc.subject | Organometallic Chemistry | en_US |
dc.subject | Radiochemistry | en_US |
dc.subject | Hot Atom Chemistry | en_US |
dc.subject | Synthetic Chemistry | en_US |
dc.subject | Medicine | en_US |
dc.subject | Radiology | en_US |
dc.subject | Diagnostic Radiology | en_US |
dc.subject | Fluorography | en_US |
dc.subject | Nuclear Medicine | en_US |
dc.subject | PET imaging | en_US |
dc.subject | Radionuclide Imaging | en_US |
dc.subject | Physics | en_US |
dc.subject | Nuclear Physics | en_US |
dc.subject | Radionuclide Generators | en_US |
dc.title | Application of Palladium-Mediated 18F-Fluorination to PET Radiotracer Development: Overcoming Hurdles to Translation | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS ONE | en_US |
dash.depositing.author | Ritter, Tobias | |
dc.date.available | 2014-02-26T12:46:25Z | |
dc.identifier.doi | 10.1371/journal.pone.0059187 | * |
dash.contributor.affiliated | Stephenson, Nickeisha A | |
dash.contributor.affiliated | Neumann, Constanze N. | |
dash.contributor.affiliated | Kamlet, Adam Seth | |
dash.contributor.affiliated | Lee, Eunsung | |
dash.contributor.affiliated | Hooker, Jacob | |
dash.contributor.affiliated | Ritter, Tobias | |