The effect of one additional driver mutation on tumor progression

DSpace/Manakin Repository

The effect of one additional driver mutation on tumor progression

Citable link to this page

 

 
Title: The effect of one additional driver mutation on tumor progression
Author: Reiter, Johannes G; Bozic, Ivana; Allen, Benjamin Isaac; Chatterjee, Krishnendu; Nowak, Martin A.

Note: Order does not necessarily reflect citation order of authors.

Citation: Reiter, Johannes G, Ivana Bozic, Benjamin Allen, Krishnendu Chatterjee, and Martin A Nowak. 2013. The effect of one additional driver mutation on tumor progression. Evolutionary Applications 6(1): 34-45.
Full Text & Related Files:
Abstract: Tumor growth is caused by the acquisition of driver mutations, which enhance the net reproductive rate of cells. Driver mutations may increase cell division, reduce cell death, or allow cells to overcome density-limiting effects. We study the dynamics of tumor growth as one additional driver mutation is acquired. Our models are based on two-type branching processes that terminate in either tumor disappearance or tumor detection. In our first model, both cell types grow exponentially, with a faster rate for cells carrying the additional driver. We find that the additional driver mutation does not affect the survival probability of the lesion, but can substantially reduce the time to reach the detectable size if the lesion is slow growing. In our second model, cells lacking the additional driver cannot exceed a fixed carrying capacity, due to density limitations. In this case, the time to detection depends strongly on this carrying capacity. Our model provides a quantitative framework for studying tumor dynamics during different stages of progression. We observe that early, small lesions need additional drivers, while late stage metastases are only marginally affected by them. These results help to explain why additional driver mutations are typically not detected in fast-growing metastases.
Published Version: doi:10.1111/eva.12020
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567469/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11800766
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters