Show simple item record

dc.contributor.authorDaniels, Rachel Fath
dc.contributor.authorChang, Hsiao-Han
dc.contributor.authorSéne, Papa Diogoye
dc.contributor.authorPark, Danny C.
dc.contributor.authorNeafsey, Daniel Edward
dc.contributor.authorSchaffner, Stephen
dc.contributor.authorHamilton, Elizabeth Julia
dc.contributor.authorLukens, Amanda Kathleen
dc.contributor.authorVan Tyne, Daria Natalie
dc.contributor.authorMboup, Souleymane
dc.contributor.authorSabeti, Pardis Christine
dc.contributor.authorNdiaye, Daouda
dc.contributor.authorWirth, Dyann Fergus
dc.contributor.authorHartl, Daniel L.
dc.contributor.authorCooke, Sarah Volkman
dc.date.accessioned2014-02-26T15:33:26Z
dc.date.issued2013
dc.identifier.citationDaniels, Rachel Fath, Hsiao-Han Chang, Papa Diogoye Séne, Danny C. Park, Daniel Edward Neafsey, Stephen Schaffner, Elizabeth Julia Hamilton, et al. 2013. Genetic surveillance detects both clonal and epidemic transmission of malaria following enhanced intervention in Senegal. PLoS ONE 8(4): e60780.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11807558
dc.description.abstractUsing parasite genotyping tools, we screened patients with mild uncomplicated malaria seeking treatment at a clinic in Thiès, Senegal, from 2006 to 2011. We identified a growing frequency of infections caused by genetically identical parasite strains, coincident with increased deployment of malaria control interventions and decreased malaria deaths. Parasite genotypes in some cases persisted clonally across dry seasons. The increase in frequency of genetically identical parasite strains corresponded with decrease in the probability of multiple infections. Further, these observations support evidence of both clonal and epidemic population structures. These data provide the first evidence of a temporal correlation between the appearance of identical parasite types and increased malaria control efforts in Africa, which here included distribution of insecticide treated nets (ITNs), use of rapid diagnostic tests (RDTs) for malaria detection, and deployment of artemisinin combination therapy (ACT). Our results imply that genetic surveillance can be used to evaluate the effectiveness of disease control strategies and assist a rational global malaria eradication campaign.en_US
dc.description.sponsorshipHuman Evolutionary Biologyen_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0060780en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617153/pdf/en_US
dash.licenseOAP
dc.subjectBiologyen_US
dc.subjectEvolutionary Biologyen_US
dc.subjectPopulation Geneticsen_US
dc.subjectGeneticsen_US
dc.subjectMicrobiologyen_US
dc.subjectProtozoologyen_US
dc.subjectParastic Protozoansen_US
dc.subjectPlasmodium Falciparumen_US
dc.subjectPopulation Biologyen_US
dc.subjectMedicineen_US
dc.subjectInfectious Diseasesen_US
dc.subjectParasitic Diseasesen_US
dc.subjectMalariaen_US
dc.subjectTropical Diseases (Non-Neglected)en_US
dc.subjectInfectious Disease Controlen_US
dc.titleGenetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegalen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorHartl, Daniel L.
dc.date.available2014-02-26T15:33:26Z
dc.identifier.doi10.1371/journal.pone.0060780*
dash.authorsorderedfalse
dash.contributor.affiliatedVan tyne, Daria
dash.contributor.affiliatedNdiaye, Daouda
dash.contributor.affiliatedHamilton, Elizabeth
dash.contributor.affiliatedVolkman, Sarah
dash.contributor.affiliatedSchaffner, Stephen
dash.contributor.affiliatedChang, Hsiao-Han
dash.contributor.affiliatedDaniels, Rachel
dash.contributor.affiliatedLukens, Amanda
dash.contributor.affiliatedNeafsey, Daniel
dash.contributor.affiliatedWirth, Dyann
dash.contributor.affiliatedHartl, Daniel
dash.contributor.affiliatedSabeti, Pardis


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record