The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity

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The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity

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Title: The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity
Author: Kook, S H; Cho, J S; Morrison, A; Wiener, E; Lee, S B; Scadden, D; Lee, B-C

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Citation: Kook, S H, J S Cho, A Morrison, E Wiener, S B Lee, D Scadden, and B-C Lee. 2013. “The purinergic P2Y14 receptor axis is a molecular determinant for organism survival under in utero radiation toxicity.” Cell Death & Disease 4 (7): e703. doi:10.1038/cddis.2013.218. http://dx.doi.org/10.1038/cddis.2013.218.
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Abstract: In utero exposure of the embryo and fetus to radiation has been implicated in malformations or fetal death, and often produces lifelong health consequences such as cancers and mental retardation. Here we demonstrate that deletion of a G-protein-coupled purinergic receptor, P2Y14, confers potent resistance to in utero radiation. Intriguingly, a putative P2Y14 receptor ligand, UDP-glucose, phenocopies the effect of P2Y14 deficiency. These data indicate that P2Y14 is a receptor governing in utero tolerance to genotoxic stress that may be pharmacologically targeted to mitigate radiation toxicity in pregnancy.
Published Version: doi:10.1038/cddis.2013.218
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730399/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11855718
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