Show simple item record

dc.contributor.authorLiu, Ching-Tien_US
dc.contributor.authorMonda, Keri L.en_US
dc.contributor.authorTaylor, Kira C.en_US
dc.contributor.authorLange, Leslieen_US
dc.contributor.authorDemerath, Ellen W.en_US
dc.contributor.authorPalmas, Walteren_US
dc.contributor.authorWojczynski, Mary K.en_US
dc.contributor.authorEllis, Jaclyn C.en_US
dc.contributor.authorVitolins, Mara Z.en_US
dc.contributor.authorLiu, Siminen_US
dc.contributor.authorPapanicolaou, George J.en_US
dc.contributor.authorIrvin, Marguerite R.en_US
dc.contributor.authorXue, Lutingen_US
dc.contributor.authorGriffin, Paula J.en_US
dc.contributor.authorNalls, Michael A.en_US
dc.contributor.authorAdeyemo, Adebowaleen_US
dc.contributor.authorLiu, Jiankangen_US
dc.contributor.authorLi, Guoen_US
dc.contributor.authorRuiz-Narvaez, Edward A.en_US
dc.contributor.authorChen, Wei-Minen_US
dc.contributor.authorChen, Fangen_US
dc.contributor.authorHenderson, Brian E.en_US
dc.contributor.authorMillikan, Robert C.en_US
dc.contributor.authorAmbrosone, Christine B.en_US
dc.contributor.authorStrom, Sara S.en_US
dc.contributor.authorGuo, Xiuqingen_US
dc.contributor.authorAndrews, Jeanette S.en_US
dc.contributor.authorSun, Yan V.en_US
dc.contributor.authorMosley, Thomas H.en_US
dc.contributor.authorYanek, Lisa R.en_US
dc.contributor.authorShriner, Danielen_US
dc.contributor.authorHaritunians, Talinen_US
dc.contributor.authorRotter, Jerome I.en_US
dc.contributor.authorSpeliotes, Elizabeth K.en_US
dc.contributor.authorSmith, Meganen_US
dc.contributor.authorRosenberg, Lynnen_US
dc.contributor.authorMychaleckyj, Josyfen_US
dc.contributor.authorNayak, Umaen_US
dc.contributor.authorSpruill, Idaen_US
dc.contributor.authorGarvey, W. Timothyen_US
dc.contributor.authorPettaway, Curtisen_US
dc.contributor.authorNyante, Sarahen_US
dc.contributor.authorBandera, Elisa V.en_US
dc.contributor.authorBritton, Angela F.en_US
dc.contributor.authorZonderman, Alan B.en_US
dc.contributor.authorRasmussen-Torvik, Laura J.en_US
dc.contributor.authorChen, Yii-Der Idaen_US
dc.contributor.authorDing, Jingzhongen_US
dc.contributor.authorLohman, Kurten_US
dc.contributor.authorKritchevsky, Stephen B.en_US
dc.contributor.authorZhao, Weien_US
dc.contributor.authorPeyser, Patricia A.en_US
dc.contributor.authorKardia, Sharon L. R.en_US
dc.contributor.authorKabagambe, Edmonden_US
dc.contributor.authorBroeckel, Ulrichen_US
dc.contributor.authorChen, Guanjieen_US
dc.contributor.authorZhou, Jieen_US
dc.contributor.authorWassertheil-Smoller, Sylviaen_US
dc.contributor.authorNeuhouser, Marian L.en_US
dc.contributor.authorRampersaud, Evadnieen_US
dc.contributor.authorPsaty, Bruceen_US
dc.contributor.authorKooperberg, Charlesen_US
dc.contributor.authorManson, JoAnn E.en_US
dc.contributor.authorKuller, Lewis H.en_US
dc.contributor.authorOchs-Balcom, Heather M.en_US
dc.contributor.authorJohnson, Karen C.en_US
dc.contributor.authorSucheston, Laraen_US
dc.contributor.authorOrdovas, Jose M.en_US
dc.contributor.authorPalmer, Julie R.en_US
dc.contributor.authorHaiman, Christopher A.en_US
dc.contributor.authorMcKnight, Barbaraen_US
dc.contributor.authorHoward, Barbara V.en_US
dc.contributor.authorBecker, Diane M.en_US
dc.contributor.authorBielak, Lawrence F.en_US
dc.contributor.authorLiu, Yongmeien_US
dc.contributor.authorAllison, Matthew A.en_US
dc.contributor.authorGrant, Struan F. A.en_US
dc.contributor.authorBurke, Gregory L.en_US
dc.contributor.authorPatel, Sanjay R.en_US
dc.contributor.authorSchreiner, Pamela J.en_US
dc.contributor.authorBorecki, Ingrid B.en_US
dc.contributor.authorEvans, Michele K.en_US
dc.contributor.authorTaylor, Hermanen_US
dc.contributor.authorSale, Michele M.en_US
dc.contributor.authorHoward, Virginiaen_US
dc.contributor.authorCarlson, Christopher S.en_US
dc.contributor.authorRotimi, Charles N.en_US
dc.contributor.authorCushman, Maryen_US
dc.contributor.authorHarris, Tamara B.en_US
dc.contributor.authorReiner, Alexander P.en_US
dc.contributor.authorCupples, L. Adrienneen_US
dc.contributor.authorNorth, Kari E.en_US
dc.contributor.authorFox, Caroline S.en_US
dc.date.accessioned2014-03-01T02:23:54Z
dc.date.issued2013en_US
dc.identifier.citationLiu, C., K. L. Monda, K. C. Taylor, L. Lange, E. W. Demerath, W. Palmas, M. K. Wojczynski, et al. 2013. “Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci.” PLoS Genetics 9 (8): e1003681. doi:10.1371/journal.pgen.1003681. http://dx.doi.org/10.1371/journal.pgen.1003681.en
dc.identifier.issn1553-7390en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11855733
dc.description.abstractCentral obesity, measured by waist circumference (WC) or waist-hip ratio (WHR), is a marker of body fat distribution. Although obesity disproportionately affects minority populations, few studies have conducted genome-wide association study (GWAS) of fat distribution among those of predominantly African ancestry (AA). We performed GWAS of WC and WHR, adjusted and unadjusted for BMI, in up to 33,591 and 27,350 AA individuals, respectively. We identified loci associated with fat distribution in AA individuals using meta-analyses of GWA results for WC and WHR (stage 1). Overall, 25 SNPs with single genomic control (GC)-corrected p-values<5.0×10−6 were followed-up (stage 2) in AA with WC and with WHR. Additionally, we interrogated genomic regions of previously identified European ancestry (EA) WHR loci among AA. In joint analysis of association results including both Stage 1 and 2 cohorts, 2 SNPs demonstrated association, rs2075064 at LHX2, p = 2.24×10−8 for WC-adjusted-for-BMI, and rs6931262 at RREB1, p = 2.48×10−8 for WHR-adjusted-for-BMI. However, neither signal was genome-wide significant after double GC-correction (LHX2: p = 6.5×10−8; RREB1: p = 5.7×10−8). Six of fourteen previously reported loci for waist in EA populations were significant (p<0.05 divided by the number of independent SNPs within the region) in AA studied here (TBX15-WARS2, GRB14, ADAMTS9, LY86, RSPO3, ITPR2-SSPN). Further, we observed associations with metabolic traits: rs13389219 at GRB14 associated with HDL-cholesterol, triglycerides, and fasting insulin, and rs13060013 at ADAMTS9 with HDL-cholesterol and fasting insulin. Finally, we observed nominal evidence for sexual dimorphism, with stronger results in AA women at the GRB14 locus (p for interaction = 0.02). In conclusion, we identified two suggestive loci associated with fat distribution in AA populations in addition to confirming 6 loci previously identified in populations of EA. These findings reinforce the concept that there are fat distribution loci that are independent of generalized adiposity.en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.relation.isversionofdoi:10.1371/journal.pgen.1003681en
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3744443/pdf/en
dash.licenseLAAen_US
dc.subjectBiologyen
dc.subjectGeneticsen
dc.subjectGenome-Wide Association Studiesen
dc.subjectMedicineen
dc.subjectMetabolic Disordersen
dc.titleGenome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Locien
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden
dc.relation.journalPLoS Geneticsen
dash.depositing.authorManson, JoAnn E.en_US
dc.date.available2014-03-01T02:23:54Z
dc.identifier.doi10.1371/journal.pgen.1003681*
dash.authorsorderedfalse
dash.contributor.affiliatedFox, Caroline
dash.contributor.affiliatedManson, JoAnn
dc.identifier.orcid0000-0002-9426-7595


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record